基础医学与临床
基礎醫學與臨床
기출의학여림상
BASIC MEDICAL SCIENCES AND CLINICS
2009年
11期
1161-1165
,共5页
邱小萍%陶宁%谭云%伍欣星
邱小萍%陶寧%譚雲%伍訢星
구소평%도저%담운%오흔성
宫颈癌%人乳头瘤病毒%人类组织相容性抗原%SBT
宮頸癌%人乳頭瘤病毒%人類組織相容性抗原%SBT
궁경암%인유두류병독%인류조직상용성항원%SBT
cervical cancer%human papillomavirus (HPV)%human leukocyte antigen (HLA)%SBT
目的 研究湖北土家族HLA-A等位基因及超型与HPV感染、宫颈癌的关联.方法 在居住地及年龄相匹配的条件下,HPV感染阳性的癌症组分别与HPV感染阳性的对照组和HPV感染阴性的对照组进行比较.癌症组100例(其中HPV感染阳性者86例),对照组187例(其中HPV感染阳性者95例,HPV感染阴性者92例).采用SBT法对最具多态性的HLA-A位点的2、3外显子进行基因型分析.结果 HPV阳性宫颈癌组与HPV阳性对照组比较,超型HLA-A3(P_(corrected)=0.015,OR=2.01,95% CI=1.26～3.21)可增加宫颈癌的易感性.HPV阳性宫颈癌组与HPV阴性对照组比较,HLA-A*0206(P_(corrected)=0.025,OR=0.20,95% CI:0.07～0.58)超型HLA-A2(P_(corrected)=0.005,OR=0.57,95% CI=0.37～0.88)可降低宫颈癌的易感性,而超型HLA-A3(P_(corrected)=0.005,OR=2.36,95% CI=1.45～3.85)同样增加宫颈癌的易感性.结论 超型HLA-A3为宫颈癌的风险因子.
目的 研究湖北土傢族HLA-A等位基因及超型與HPV感染、宮頸癌的關聯.方法 在居住地及年齡相匹配的條件下,HPV感染暘性的癌癥組分彆與HPV感染暘性的對照組和HPV感染陰性的對照組進行比較.癌癥組100例(其中HPV感染暘性者86例),對照組187例(其中HPV感染暘性者95例,HPV感染陰性者92例).採用SBT法對最具多態性的HLA-A位點的2、3外顯子進行基因型分析.結果 HPV暘性宮頸癌組與HPV暘性對照組比較,超型HLA-A3(P_(corrected)=0.015,OR=2.01,95% CI=1.26～3.21)可增加宮頸癌的易感性.HPV暘性宮頸癌組與HPV陰性對照組比較,HLA-A*0206(P_(corrected)=0.025,OR=0.20,95% CI:0.07～0.58)超型HLA-A2(P_(corrected)=0.005,OR=0.57,95% CI=0.37～0.88)可降低宮頸癌的易感性,而超型HLA-A3(P_(corrected)=0.005,OR=2.36,95% CI=1.45～3.85)同樣增加宮頸癌的易感性.結論 超型HLA-A3為宮頸癌的風險因子.
목적 연구호북토가족HLA-A등위기인급초형여HPV감염、궁경암적관련.방법 재거주지급년령상필배적조건하,HPV감염양성적암증조분별여HPV감염양성적대조조화HPV감염음성적대조조진행비교.암증조100례(기중HPV감염양성자86례),대조조187례(기중HPV감염양성자95례,HPV감염음성자92례).채용SBT법대최구다태성적HLA-A위점적2、3외현자진행기인형분석.결과 HPV양성궁경암조여HPV양성대조조비교,초형HLA-A3(P_(corrected)=0.015,OR=2.01,95% CI=1.26～3.21)가증가궁경암적역감성.HPV양성궁경암조여HPV음성대조조비교,HLA-A*0206(P_(corrected)=0.025,OR=0.20,95% CI:0.07～0.58)초형HLA-A2(P_(corrected)=0.005,OR=0.57,95% CI=0.37～0.88)가강저궁경암적역감성,이초형HLA-A3(P_(corrected)=0.005,OR=2.36,95% CI=1.45～3.85)동양증가궁경암적역감성.결론 초형HLA-A3위궁경암적풍험인자.
Objective To study the relationship among HLA-A alleles, supertype, HPV infection and cervical cancer in Tu Nationality of Hubei province. Methods As a case-control surevy. The comparisons included the comparison between HPV positive cases and HPV positive women in control group, and the comparison between HPV positive cases and HPV negative women in control group. Number of cases was 100 ( HPV positive in 86) , and control was 187 ( HPV positive in 95 and HPV negative in 92). The most polymorphism of 2 and 3 exons of the HLA-A alleles were analyzed by the high-resolution typing method-sequence-based typing( SBT). Results Compar-ison between HPV positive cases and HPV positive control women. Supertype HLA-A3 (P_(corrected) = 0. 005, OR = 2. 36, 95% CI = 1. 45～3. 85) was risk factors. Comparison between HPV positive cases and HPV negative control women, HLA-A * 0206 alleles (P_(corrected)=0. 025,OR =0. 20,95% CI =0. 07～ 0. 58 ) supertype HLA-A2 ( P_(corrected) = 0.005 , OR = 0. 57 ,95% CI = 0. 37 ～ 0. 88 ) was protective factor. Supertype HLA-A3 ( P_(corrected) = 0. 005 , OR = 2. 36, 95% CI = 1. 45～3. 85) was also related to the susceptibility of cervical carcinoma. Conclusion Supertype HLA-A3 is a risk factor of cervical cancer.
