国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2011年
6期
319-325
,共7页
R-Ras%小G蛋白%生物学功能
R-Ras%小G蛋白%生物學功能
R-Ras%소G단백%생물학공능
R-Ras%Small G protein%Biological functions
R-Ras作为Ras家族的成员之一,位于质膜起着“分子开关”的作用；作为GTP(guanine nucleotide binding protein)结合蛋白类,结合GTP时表现GTP酶的活性,处于激活状态,能够与下游因子相互作用,开启信号通路,调节细胞增殖,促进细胞凋亡,抑制细胞运动,调节细胞形态,调控细胞黏附分子,构塑神经突触,抑制血管再生和介导胞吐等相应的细胞生物学功能,另外,R - Ras信号通路异常与人类的肿瘤发生发展密切相关.
R-Ras作為Ras傢族的成員之一,位于質膜起著“分子開關”的作用；作為GTP(guanine nucleotide binding protein)結閤蛋白類,結閤GTP時錶現GTP酶的活性,處于激活狀態,能夠與下遊因子相互作用,開啟信號通路,調節細胞增殖,促進細胞凋亡,抑製細胞運動,調節細胞形態,調控細胞黏附分子,構塑神經突觸,抑製血管再生和介導胞吐等相應的細胞生物學功能,另外,R - Ras信號通路異常與人類的腫瘤髮生髮展密切相關.
R-Ras작위Ras가족적성원지일,위우질막기착“분자개관”적작용；작위GTP(guanine nucleotide binding protein)결합단백류,결합GTP시표현GTP매적활성,처우격활상태,능구여하유인자상호작용,개계신호통로,조절세포증식,촉진세포조망,억제세포운동,조절세포형태,조공세포점부분자,구소신경돌촉,억제혈관재생화개도포토등상응적세포생물학공능,령외,R - Ras신호통로이상여인류적종류발생발전밀절상관.
As a member of the Ras family of small GTPases,R-Ras plays a molecular switches role in cell signaling,between the two interconvertible forms:GDP-bound inactive and GTP-bound active forms.R-RasGTP transduces upstream signal to a downstream effectors.It regulates biological functions such as cell adhesion,apoptosis,movement,morphology,adhesion molecules,nerve synapses,differentiation,angiogenesis and exocytosis.Furthermore R-Ras signaling have been implicated in various cancer.
