中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2008年
9期
1413-1414
,共2页
磷酸丙酮酸水合酶%缺氧缺血,脑%婴儿,新生
燐痠丙酮痠水閤酶%缺氧缺血,腦%嬰兒,新生
린산병동산수합매%결양결혈,뇌%영인,신생
Phosphopyr%Hypoxia-ischemia,brain%Infant,newbomuvate hydratase
目的 探讨脑损伤患儿血中神经元特异性烯醇化酶变化与远期神经系统发育障碍的相关性,以期对新生儿脑损伤预后及时预报,为早期干预提供理论依据.方法 选择40例围生期脑损伤新生儿为研究对象,同时选择20例同期出生的健康新生儿为对照组,两组均于生后72 h进行检测血浆神经元特异性烯醇化酶,并对两组定期追踪发育情况,以盖塞尔量表评价.经统计学处理分析神经元特异性烯醇化酶与围生期脑损伤患儿远期神经系统发育障碍的相关性.结果 脑损伤组血神经元特异性烯醇化酶浓度为(20.5±6.9)μg/L,明显高于健康对照组的(7.8±3.8)μg/L(t=4.85,P＜0.01);脑损伤组15月龄盖塞尔量表评价发育商可疑组生后3 d血神经元特异性烯醇化酶浓度为(17.6±5.1)μg/L,明显高于发育商正常组的(12.07±1.86)μg/L(t=3.73,P＜0.01),发育商异常组生后3 d血神经元特异性烯醇化酶浓度为(27±7.4)μg/L,明显高于发育商正常组的(12.07±1.86)μg/L(t=3.94,P＜0.01).结论 神经元特异性烯醇化酶变化可作为早期诊断围生儿脑损伤的主要指标以及远期预后指标.
目的 探討腦損傷患兒血中神經元特異性烯醇化酶變化與遠期神經繫統髮育障礙的相關性,以期對新生兒腦損傷預後及時預報,為早期榦預提供理論依據.方法 選擇40例圍生期腦損傷新生兒為研究對象,同時選擇20例同期齣生的健康新生兒為對照組,兩組均于生後72 h進行檢測血漿神經元特異性烯醇化酶,併對兩組定期追蹤髮育情況,以蓋塞爾量錶評價.經統計學處理分析神經元特異性烯醇化酶與圍生期腦損傷患兒遠期神經繫統髮育障礙的相關性.結果 腦損傷組血神經元特異性烯醇化酶濃度為(20.5±6.9)μg/L,明顯高于健康對照組的(7.8±3.8)μg/L(t=4.85,P＜0.01);腦損傷組15月齡蓋塞爾量錶評價髮育商可疑組生後3 d血神經元特異性烯醇化酶濃度為(17.6±5.1)μg/L,明顯高于髮育商正常組的(12.07±1.86)μg/L(t=3.73,P＜0.01),髮育商異常組生後3 d血神經元特異性烯醇化酶濃度為(27±7.4)μg/L,明顯高于髮育商正常組的(12.07±1.86)μg/L(t=3.94,P＜0.01).結論 神經元特異性烯醇化酶變化可作為早期診斷圍生兒腦損傷的主要指標以及遠期預後指標.
목적 탐토뇌손상환인혈중신경원특이성희순화매변화여원기신경계통발육장애적상관성,이기대신생인뇌손상예후급시예보,위조기간예제공이론의거.방법 선택40례위생기뇌손상신생인위연구대상,동시선택20례동기출생적건강신생인위대조조,량조균우생후72 h진행검측혈장신경원특이성희순화매,병대량조정기추종발육정황,이개새이량표평개.경통계학처리분석신경원특이성희순화매여위생기뇌손상환인원기신경계통발육장애적상관성.결과 뇌손상조혈신경원특이성희순화매농도위(20.5±6.9)μg/L,명현고우건강대조조적(7.8±3.8)μg/L(t=4.85,P＜0.01);뇌손상조15월령개새이량표평개발육상가의조생후3 d혈신경원특이성희순화매농도위(17.6±5.1)μg/L,명현고우발육상정상조적(12.07±1.86)μg/L(t=3.73,P＜0.01),발육상이상조생후3 d혈신경원특이성희순화매농도위(27±7.4)μg/L,명현고우발육상정상조적(12.07±1.86)μg/L(t=3.94,P＜0.01).결론 신경원특이성희순화매변화가작위조기진단위생인뇌손상적주요지표이급원기예후지표.
Objective To investigate the pefinatal infant brain damage in the blcod of neuron specific enolase and long-term changes in the development of nervous system disordem related to the neonatal brain injury prognosis timely predictions for the early intervention and provide a theoretical basis.Methods 40 cases of periatal brain injury in newborns were selected for the study.20 patients over the same period of normal newborns assigned to the control groups.both groups in the 72 hours after birth within the collected blood samples submitted preservation of the neuronspecific enolase enzyme,and rely follow-up of the two groups,so as to cover Gesell development scale statistical analysis of neuron specific enolase and perinatal brain damage in children with long-term development of nervous system disorder relevant.Results Brain injury group blood neurompeeifie enolase concentrations were higher:15-month-old brain-injury group scale evaluation of sale to group health suspicious after three clays of Mood neuronspecific enolase concentrations significantly higher to the development of the normal group.Conclusion Neuronspecific enolase may change as early diagnosis of perinatal brain injury,as well aft the main indicators of the long-term prognosis.
