中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
27期
22-24
,共3页
疱疹,带状%更昔洛韦%治疗结果%卡介菌多糖核酸
皰疹,帶狀%更昔洛韋%治療結果%卡介菌多糖覈痠
포진,대상%경석락위%치료결과%잡개균다당핵산
Herpes zoster%Ganciclovir%Treatment outcome%Bacillus Calmette-Guerin polysaccharide and nucleic acid
目的 探讨更昔洛韦联合卡介菌多糖核酸治疗带状疱疹的临床疗效.方法 将86例带状疱疹患者按随机数字表法分为观察组和对照组,每组43例.对照组单纯应用更昔洛韦治疗;观察组在此基础上联合应用卡介菌多糖核酸治疗,观察并比较两组疗效、修复皮肤损害(止疱、结痂)时间和疼痛缓解时间、后遗神经痛发生率和不良反应情况.结果 两组患者均顺利完成治疗,没有因为无法耐受药物而退出者.观察组止疱、结痂和疼痛缓解时间均较对照组明显缩短,差异有统计学意义(P＜0.05);后遗神经痛发生率明显低于对照组,差异有统计学意义(P＜0.05);治疗14 d后观察组有效率为90.7%(39/43),与对照组的74.4%(32/43)比较差异有统计学意义(P＜0.05);两组均无严重不良反应发生.结论 更昔洛韦联合卡介菌多糖核酸治疗带状疱疹疗效确切,安全可行.
目的 探討更昔洛韋聯閤卡介菌多糖覈痠治療帶狀皰疹的臨床療效.方法 將86例帶狀皰疹患者按隨機數字錶法分為觀察組和對照組,每組43例.對照組單純應用更昔洛韋治療;觀察組在此基礎上聯閤應用卡介菌多糖覈痠治療,觀察併比較兩組療效、脩複皮膚損害(止皰、結痂)時間和疼痛緩解時間、後遺神經痛髮生率和不良反應情況.結果 兩組患者均順利完成治療,沒有因為無法耐受藥物而退齣者.觀察組止皰、結痂和疼痛緩解時間均較對照組明顯縮短,差異有統計學意義(P＜0.05);後遺神經痛髮生率明顯低于對照組,差異有統計學意義(P＜0.05);治療14 d後觀察組有效率為90.7%(39/43),與對照組的74.4%(32/43)比較差異有統計學意義(P＜0.05);兩組均無嚴重不良反應髮生.結論 更昔洛韋聯閤卡介菌多糖覈痠治療帶狀皰疹療效確切,安全可行.
목적 탐토경석락위연합잡개균다당핵산치료대상포진적림상료효.방법 장86례대상포진환자안수궤수자표법분위관찰조화대조조,매조43례.대조조단순응용경석락위치료;관찰조재차기출상연합응용잡개균다당핵산치료,관찰병비교량조료효、수복피부손해(지포、결가)시간화동통완해시간、후유신경통발생솔화불량반응정황.결과 량조환자균순리완성치료,몰유인위무법내수약물이퇴출자.관찰조지포、결가화동통완해시간균교대조조명현축단,차이유통계학의의(P＜0.05);후유신경통발생솔명현저우대조조,차이유통계학의의(P＜0.05);치료14 d후관찰조유효솔위90.7%(39/43),여대조조적74.4%(32/43)비교차이유통계학의의(P＜0.05);량조균무엄중불량반응발생.결론 경석락위연합잡개균다당핵산치료대상포진료효학절,안전가행.
Objective To investigate the clinical efficacy of ganciclovir combined with Bacillus Calmette-Guerin polysaccharide nucleic acid (BCG-PSN) for the treatment of herpes zoster. Methods Eighty-six cases with herpes zoster were randomly divided into study group and control group, 43 cases in each group. Patients of control group received simple ganciclovir treatment; while patients of the study group received BCG-PSN on this basis, then to observe and compare the efficacy, the repair time of skin lesions (herpes stopping, surface deposition), odynolysis time, remained neuralgia incidence and adverse reactions of two groups. Results Patients of two groups all completed the experiment successfully, no one withdraw from this trial because of no tolerance of drugs. The herpes stopping and surface deposition time and odynolysis time of study group were significantly shorter than those of control group, the difference was statistically significant (P＜0.05 ); the remained neuralgia incidence was significantly lower than that of control group,the difference was statistically significant (P＜0.05); the effective rate of study group in 14 days after treatment was 90.7% (39/43) and significantly higher than that of control group [74.4% (32/43)], the difference was statistically significant (P ＜ 0.05);there were no serious adverse reactions occurred in two groups. Conclusion Application of ganciclovir combined with BCG-PSN for the treatment of herpes zoster has certain efficacy, it is feasible and safe.
