中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
13期
24-26
,共3页
丁思华%孙学玉%曹庆博%王修卫
丁思華%孫學玉%曹慶博%王脩衛
정사화%손학옥%조경박%왕수위
心房颤动%心房扑动%利钠肽,脑
心房顫動%心房撲動%利鈉肽,腦
심방전동%심방복동%리납태,뇌
Atrial fibrillation%Atrial flutter%Natriuretic peptide,brain
目的 观察阵发性心房颤动和心房扑动患者血清脑钠肽(BNP)水平,并探讨其临床意义.方法 选择非瓣膜性心脏病阵发性心房扑动患者126例(心房扑动组)、阵发性心房颤动患者96例(心房颤动组)及对照组72例作为研究对象.其中心房扑动组中,24 h内转复42例(A组),24～48h转复51例(B组),48h内未转复33例(C组).采用酶联免疫吸附法测定各组血清BNP水平,应用超声心动图测定各组左房内径(LAD)和左室射血分数(LVEF)并进行比较.结果 A、B、c组和心房颤动组BNP水平分别为(764.9±123.3)、(857.8±106.2)、(975.3±99.5)、(1137.2±113.2)ng/L,明显高于对照组的(251.3±42.5)ng/L,差异有统计学意义(P<0.05),而A、B、C组中BNP水平依次升高,两两比较差异有统计学意义(P<0.05);心房颤动组BNP水平明显高于A、B、C组(P<0.05).A、B、C组和心房颤动组LAD分别为(4.11±0.49)、(3.97±0.50)、(4.19±0.76)、(4.08±0.51)cm,明显高于对照组的(3.22±0.87)cm,差异有统计学意义(P<0.05),而A、B、C组与心房颤动组LAD比较差异无统计学意义(P>0.05).各组间LVEF比较差异无统计学意义(P>0.05).结论 阵发性心房颤动与心房扑动都是促进BNP分泌的重要因素,BNP对预测阵发性心房扑动的转复效果具有重要的临床意义.
目的 觀察陣髮性心房顫動和心房撲動患者血清腦鈉肽(BNP)水平,併探討其臨床意義.方法 選擇非瓣膜性心髒病陣髮性心房撲動患者126例(心房撲動組)、陣髮性心房顫動患者96例(心房顫動組)及對照組72例作為研究對象.其中心房撲動組中,24 h內轉複42例(A組),24～48h轉複51例(B組),48h內未轉複33例(C組).採用酶聯免疫吸附法測定各組血清BNP水平,應用超聲心動圖測定各組左房內徑(LAD)和左室射血分數(LVEF)併進行比較.結果 A、B、c組和心房顫動組BNP水平分彆為(764.9±123.3)、(857.8±106.2)、(975.3±99.5)、(1137.2±113.2)ng/L,明顯高于對照組的(251.3±42.5)ng/L,差異有統計學意義(P<0.05),而A、B、C組中BNP水平依次升高,兩兩比較差異有統計學意義(P<0.05);心房顫動組BNP水平明顯高于A、B、C組(P<0.05).A、B、C組和心房顫動組LAD分彆為(4.11±0.49)、(3.97±0.50)、(4.19±0.76)、(4.08±0.51)cm,明顯高于對照組的(3.22±0.87)cm,差異有統計學意義(P<0.05),而A、B、C組與心房顫動組LAD比較差異無統計學意義(P>0.05).各組間LVEF比較差異無統計學意義(P>0.05).結論 陣髮性心房顫動與心房撲動都是促進BNP分泌的重要因素,BNP對預測陣髮性心房撲動的轉複效果具有重要的臨床意義.
목적 관찰진발성심방전동화심방복동환자혈청뇌납태(BNP)수평,병탐토기림상의의.방법 선택비판막성심장병진발성심방복동환자126례(심방복동조)、진발성심방전동환자96례(심방전동조)급대조조72례작위연구대상.기중심방복동조중,24 h내전복42례(A조),24～48h전복51례(B조),48h내미전복33례(C조).채용매련면역흡부법측정각조혈청BNP수평,응용초성심동도측정각조좌방내경(LAD)화좌실사혈분수(LVEF)병진행비교.결과 A、B、c조화심방전동조BNP수평분별위(764.9±123.3)、(857.8±106.2)、(975.3±99.5)、(1137.2±113.2)ng/L,명현고우대조조적(251.3±42.5)ng/L,차이유통계학의의(P<0.05),이A、B、C조중BNP수평의차승고,량량비교차이유통계학의의(P<0.05);심방전동조BNP수평명현고우A、B、C조(P<0.05).A、B、C조화심방전동조LAD분별위(4.11±0.49)、(3.97±0.50)、(4.19±0.76)、(4.08±0.51)cm,명현고우대조조적(3.22±0.87)cm,차이유통계학의의(P<0.05),이A、B、C조여심방전동조LAD비교차이무통계학의의(P>0.05).각조간LVEF비교차이무통계학의의(P>0.05).결론 진발성심방전동여심방복동도시촉진BNP분비적중요인소,BNP대예측진발성심방복동적전복효과구유중요적림상의의.
Objective To observe the changes of serum brain natriuretic peptide(BNP)and its clinical significance in patients with paroxysmal atrial fibrillation and atrial flutter.Methods All the patients with nonvalvular heart diseases were divided into 3 groups:control group(72 patients),atrial flutter group(126 patients),and atrial fibrillation group(96 patients).Meanwhile the patients in atrial flutter group were divided into 3 groups: the patients achieving cardioversion in 24 hours(group A),the patients achieving cardioversion in 24-48 hours(group B)and the patients losing cardioversion in 48 hours(group C).The serum levels of BNP were measured by ELISA method after admission,and the left atrium diameter(LAD)and left ventricular ejection fraction(LVEF)were described by ultrasound.Results The serum level of BNP in atrial flutter group(group A,B,C)and atrial fibrillation group was higher than that in control group[(764.9 ± 123.3),(857.8±106.2),(975.3±99.5),(1137.2 ± 113.2)ng/L vs(251.3 ± 42.5)ng/L,P <0.05].Among the A,B,C groups,the serum level of BNP increased in order,and showed statistical differences(P < 0.05).The serum level of BNP in atrial fibrillation group was higher than that in group A,B,C(P < 0.05).The LAD in group A,B,C and atrial fibrillation group[(4.11 ± 0.49),(3.97 ± 0.50),(4.19 ±0.76),(4.08±0.51)cm]was higher than that in control group[(3.22 ± 0.87)cm](P < 0.05),but there was no statistical differences between group A,B,C and atrial fibrillation group(P > 0.05).The level of LVEF had no statistical differences among the groups.Conclusion Paroxysmal atrial fibrillation and atrial flutter have enhanced effect on the secretion of BNP,which plays an important role in predicting the results of drug conversion.
