CAJ | 학술논문

目的探讨粪便钙卫蛋白(FCP)判断消化性溃疡(PU)活动性的临床价值,并与常规胃镜检查结果行对比研究.方法胃镜确诊消化性溃疡患者62例,胃镜检查后3 d内留取粪便5～10 g,应用ELISA法检测粪便钙卫蛋白;同时收集患者病史及临床资料.正常对照组30例,均为健康体检正常的成人.结果 62例Pu组FCP检测值(154.72μg/g)显著高于正常对照组(25.18μg/g)(P<0.001);PU组活动期FCP检测值(318.34μg/g)与瘢痕期(54.10μg/g)、对照组(25.18μg/g)相比较也均有统计学意义(P<0.01);后两者之间的差异无统计学意义(P>0.05).FCP检测值与溃疡部位、大小、数目之间无明显关系(P>0.05).PU组中上消化道出血者FCP检测值(1257.41 μg/g)显著高于其他症状者(92.77μg/g)(P<0.001).结论 FCP的表达水平与消化性溃疡患者溃疡活动性及临床表现密切相关,FCP可作为检测消化性溃疡患者溃疡活动性指标之一.
목적 탐토분편개위단백(FCP)판단소화성궤양(PU)활동성적림상개치,병여상규위경검사결과행대비연구.방법 위경학진소화성궤양환자62례,위경검사후3 d내류취분편5～10 g,응용ELISA법검측분편개위단백;동시수집환자병사급림상자료.정상대조조30례,균위건강체검정상적성인.결과 62례Pu조FCP검측치(154.72μg/g)현저고우정상대조조(25.18μg/g)(P<0.001);PU조활동기FCP검측치(318.34μg/g)여반흔기(54.10μg/g)、대조조(25.18μg/g)상비교야균유통계학의의(P<0.01);후량자지간적차이무통계학의의(P>0.05).FCP검측치여궤양부위、대소、수목지간무명현관계(P>0.05).PU조중상소화도출혈자FCP검측치(1257.41 μg/g)현저고우기타증상자(92.77μg/g)(P<0.001).결론 FCP적표체수평여소화성궤양환자궤양활동성급림상표현밀절상관,FCP가작위검측소화성궤양환자궤양활동성지표지일.
Objective To explore the clinical value of fecal calprotectin (FCP) in peptic ulcer (PU) as an non-invasive indicator of disease activity compared with gastroscope. Methods The study was conducted in 62 patients with PU confirmed by endoscopy ( PU group) and 30 subjects with normal findings under endoscopy ( control group). Fecal sample ( weight 5-10 g) was collected within 3 days after endoscopy and FCP was measured by emzyme-linked immunosorbent assay (ELISA). The case history and clinical data were collected as well. Results The level of FCP in PU group was significantly higher than that in control group ( 154. 72 μg/g vs. 25. 18 μg/g, P < 0.001 ). In patients with PU at active stage ( n = 32), the level of FCP was significantly higher than that at scar stage (n =30,318.34 μg/g vs. 54. 10 μg/g, P <0. 01 ), and that in control group (25.18 μg/g, P <0.01), while there was no significant difference in FCP between the latter two groups ( P >0. 05 ). The level of FCP had no significant correlation with the location, size or number of the ulcer. Among patients in PU group, the level of FCP in patients presented with haematemesis or melena ( n = 20) was significantly higher than that in patients presented with other symptoms ( n = 42, 1257. 41 μg/g vs. 92. 77 μg/g, P < 0. 01 ). Conclusion The level of FCP is closely correlated with the activity of PU, which is significantly higher at active stage than that at scar stage, as well as in PU patients with bleeding than those without. Measurement of FCP is a convenient and noninvasive method with well compliance of patients, which might be used as an indicator of disease activity in PU.