CAJ | 학술논문

目的观察视神经脊髓炎(NMO)与多发性硬化(MS)患者血清碱性磷酸酶(ALP)、谷氨酰转移酶(GGn水平.方法在中山大学附属第三医院脱髓鞘疾病数据库中调取自2007年1月至2010年3月收治的177例NMO、MS患者资料及85例同期健康体检者资料,分析其血清ALP、GGT水平,探讨其与年龄、病程、发作次数、EDSS评分的关系.结果 NMO组患者血清ALP、GGT水平较MS组及对照组增高,进一步观察发现NMO患者血清ALP水平在病灶活动期时亦高于MS患者,且男性NMO患者血清ALP水平、女性NMO患者血清GGT水平均高于MS组与对照组,差异有统计学意义(P<0.05).NMO患者血清GGT水平与其年龄、发病次数呈正相关(p<0.05).结论 ALP、GGT在NMO、MS患者血清中含量不同,在一定程度上有助于鉴别诊断这两种疾病.
목적 관찰시신경척수염(NMO)여다발성경화(MS)환자혈청감성린산매(ALP)、곡안선전이매(GGn수평.방법 재중산대학부속제삼의원탈수초질병수거고중조취자2007년1월지2010년3월수치적177례NMO、MS환자자료급85례동기건강체검자자료,분석기혈청ALP、GGT수평,탐토기여년령、병정、발작차수、EDSS평분적관계.결과 NMO조환자혈청ALP、GGT수평교MS조급대조조증고,진일보관찰발현NMO환자혈청ALP수평재병조활동기시역고우MS환자,차남성NMO환자혈청ALP수평、녀성NMO환자혈청GGT수평균고우MS조여대조조,차이유통계학의의(P<0.05).NMO환자혈청GGT수평여기년령、발병차수정정상관(p<0.05).결론 ALP、GGT재NMO、MS환자혈청중함량불동,재일정정도상유조우감별진단저량충질병.
Objective To investigate the serum alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (GGT) levels in patients with neuromyelitis optica (NMO) and multiple sclerosis (MS).Methods Serum ALP and GGT levels in patients with NMO and MS from the database of demyelinating diseases in our hospital were analyzed.Eighty-five healthy controls were chosen.The differences of serum ALP and GGT levels in patient groups and controls were compared, and the correlations between clinical features (age of the subjects, course of disease, times of relapse and scores of EDSS) and both ALP and GGT levels were analyzed. Results The serum ALP and GGT levels in patients with NMO were significantly higher than those in patients with MS and the controls (P<0.05).Patients with NMO still had significantly higher serum ALP level in acute phase than patients with MS,and the serum ALP levels in male patients with NMO and the serum GGT levels in female patients with NMO were, respectively,statistically higher than that of male patients with MS and female patients with MS (P<0.05). In patients with NMO, significantly positive correlations between serum GGT level and both age and times of relapse were noted (P<0.05). Conclusion Serum ALP and GGT levels differ in patients with NMO and MS, indicating their differential diagnostic value in NMO and MS to certain extent.