中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2010年
4期
252-254
,共3页
甲状腺癌%妊娠
甲狀腺癌%妊娠
갑상선암%임신
Thyroid cancer%Pregnancy
目的 研究妊娠对分化型甲状腺癌的影响.方法 回顾性对照分析我院头颈外科收治的妊娠相关甲状腺癌125例(包括分娩前9个月内、分娩后1年内确诊的甲状腺癌)为妊娠相关组和同年龄段非妊娠期女性患者691例(非妊娠组)的临床资料.结果 甲状腺癌术后颈部复发转移,妊娠相关组28例(22.4%),非妊娠组90例(13%),妊娠相关组甲状腺癌术后颈部复发转移高于非妊娠组(P＜0.05).妊娠相关组肿瘤最大直径平均为2.6 cm,非妊娠组2.1 cm.妊娠相关组多灶性癌19例(19.6%),非妊娠组58例(9.6%)(P＜0.05).妊娠相关组甲状腺包膜外侵犯23例(23.7%),非妊娠组65例(10.8%)(P＜0.05).妊娠相关组中央区和侧颈部淋巴结转移分别为67例(53.6%)和35例(28%),非妊娠组分别为296例(42.8%)和117例(16.9%)(P＜0.05).妊娠相关组淋巴结外侵19例(15.2%),非妊娠组32(4.6%)(P＜0.05).结论 妊娠使分化型甲状腺癌更易出现包膜外侵犯、多灶性癌、颈部淋巴结转移和淋巴结外侵,可能促使甲状腺癌恶化.对于甲状腺癌术后的患者,妊娠可能增加其颈部复发转移的风险.但妊娠不影响甲状腺癌的病理分期,预后良好.
目的 研究妊娠對分化型甲狀腺癌的影響.方法 迴顧性對照分析我院頭頸外科收治的妊娠相關甲狀腺癌125例(包括分娩前9箇月內、分娩後1年內確診的甲狀腺癌)為妊娠相關組和同年齡段非妊娠期女性患者691例(非妊娠組)的臨床資料.結果 甲狀腺癌術後頸部複髮轉移,妊娠相關組28例(22.4%),非妊娠組90例(13%),妊娠相關組甲狀腺癌術後頸部複髮轉移高于非妊娠組(P＜0.05).妊娠相關組腫瘤最大直徑平均為2.6 cm,非妊娠組2.1 cm.妊娠相關組多竈性癌19例(19.6%),非妊娠組58例(9.6%)(P＜0.05).妊娠相關組甲狀腺包膜外侵犯23例(23.7%),非妊娠組65例(10.8%)(P＜0.05).妊娠相關組中央區和側頸部淋巴結轉移分彆為67例(53.6%)和35例(28%),非妊娠組分彆為296例(42.8%)和117例(16.9%)(P＜0.05).妊娠相關組淋巴結外侵19例(15.2%),非妊娠組32(4.6%)(P＜0.05).結論 妊娠使分化型甲狀腺癌更易齣現包膜外侵犯、多竈性癌、頸部淋巴結轉移和淋巴結外侵,可能促使甲狀腺癌噁化.對于甲狀腺癌術後的患者,妊娠可能增加其頸部複髮轉移的風險.但妊娠不影響甲狀腺癌的病理分期,預後良好.
목적 연구임신대분화형갑상선암적영향.방법 회고성대조분석아원두경외과수치적임신상관갑상선암125례(포괄분면전9개월내、분면후1년내학진적갑상선암)위임신상관조화동년령단비임신기녀성환자691례(비임신조)적림상자료.결과 갑상선암술후경부복발전이,임신상관조28례(22.4%),비임신조90례(13%),임신상관조갑상선암술후경부복발전이고우비임신조(P＜0.05).임신상관조종류최대직경평균위2.6 cm,비임신조2.1 cm.임신상관조다조성암19례(19.6%),비임신조58례(9.6%)(P＜0.05).임신상관조갑상선포막외침범23례(23.7%),비임신조65례(10.8%)(P＜0.05).임신상관조중앙구화측경부림파결전이분별위67례(53.6%)화35례(28%),비임신조분별위296례(42.8%)화117례(16.9%)(P＜0.05).임신상관조림파결외침19례(15.2%),비임신조32(4.6%)(P＜0.05).결론 임신사분화형갑상선암경역출현포막외침범、다조성암、경부림파결전이화림파결외침,가능촉사갑상선암악화.대우갑상선암술후적환자,임신가능증가기경부복발전이적풍험.단임신불영향갑상선암적병리분기,예후량호.
Objective To study the impact of pregnancy on differentiated thyroid cancer. Methods Retrospective comparative analysis were made between pregnancy-related thyroid cancer patients ( including nine months before delivery and one year after delivery) and the age-matched non-pregnancy-related thyroid cancer patients treated in the Department of head and neck, Fudan University Shanghai Cancer Center. Results There were 125 cases of pregnancy-related thyroid cancer patients from 1998 to 2008, including 28 cases (22.4%) of neck recurrence and metastasis after the surgery of thyroid cancer, meanwhile there were 691 cases of the agematched non-pregnancy thyroid cancer patients, including 90 cases ( 13% ) of neck recurrence and metastasis after the surgery of thyroid cancer. The rate of neck recurrence and metastasis after the surgery of thyroid cancer in the pregnancy-related group was higher than that in the non-pregnancy related group ( P ＜ 0.05). The maximum diameter of tumor in the pregnancy-related group and the non-pregnancy group is 2. 1 cm and 2.6cm respectively.There were 19 cases of multi-focal cancer ( 19.6% ) in the pregnancy-related group and 58 cases (9. 6% ) in the non-pregnant group, P ＜0.05. There were 23 patients (23.7%) of extrathyroid invasion in the pregnancy-related group and 65 patients ( 10.8% ) in the non-pregnant group, P ＜0.05. There were 67 cases (53.6%) and 35 cases (28%) of the central and lateral cervical lymph node metastasis in the pregnancy-related group respectively and 296 cases (42.8%) and 117 cases (16. 9% )in the non-pregnant group, P ＜0.05. There were 19 cases (15.2%) of extralymph invasion in the pregnancy-related group and 32 cases (4.6%) in the non-pregnant group, P ＜ 0.05. Conclusions The incidence of Extrathyroid invasion, multi-focal cancer, cervieal lymph node metastasis and extralymph invasion of the differentiated thyroid cancer is higher in pregnancy-related patients.Pregnancy may deteriorate the prognosis of thyroid cancer. For patients after the surgery of thyroid cancer, pregnancy may increase the risk of neck recurrence and metastasis. However, pregnancy does not affect the stage of thyroid cancer and the prognosis is still good.
