CAJ | 학술논문

胱冬酶(caspase)是一组执行细胞凋亡的主要酶类.近年来的研究表明,胱冬酶参与多种疾病的发生和发展,特别是在肿瘤和神经系统疾病中.其中,胱冬酶-9是该家族最重要的启动分子之一.文章综述了胱冬酶-9的结构特点、活化与调节以及对细胞凋亡的调控机制,并简述其与缺血性脑血管病的联系.
광동매(caspase)시일조집행세포조망적주요매류.근년래적연구표명,광동매삼여다충질병적발생화발전,특별시재종류화신경계통질병중.기중,광동매-9시해가족최중요적계동분자지일.문장종술료광동매-9적결구특점、활화여조절이급대세포조망적조공궤제,병간술기여결혈성뇌혈관병적련계.
Caspases are a group of enzymes mainly for the execution of apoptosis.In recent years,studies have shown that caspases participate in the occurrence and development of many diseases,especially tumors and nervous system diseases.Of those,caspase-9 is one of the most important initiating molecules.This article reviews the structural characteristics,activation and regulation of caspase-9,its regulation mechanism of apoptosis,and briefly describes its relation with ischemic cerebrovascular disease.