中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
6期
23-25
,共3页
龙琼华%莫奕彩%朱秀风%刘进琼
龍瓊華%莫奕綵%硃秀風%劉進瓊
룡경화%막혁채%주수풍%류진경
宫颈肿瘤%静脉%动脉
宮頸腫瘤%靜脈%動脈
궁경종류%정맥%동맥
Uterine cervical neoplasms%Veins%Arteries
目的 对比分析静脉和动脉不同给药途径新辅助化疗治疗局部晚期宫颈癌(LACC)的临床疗效和不良反应.方法 对宫颈肿瘤直径≥4 cm、国际妇产科联盟(FIGO)分期Ⅰ B～ⅡB期的LACC患者分别采用静脉途径化疗(静脉组,36例)和动脉途径化疗(动脉组,34例),观察并比较其化疗效果、不良反应等.结果 两组患者54例获得近期部分缓解,总有效率为77.1%(54/70),其中静脉组为72.2%(26/36),动脉组为82.4%(28/34),两组比较差异无统计学意义(P＞0.05).静脉组发生的胃肠道反应、骨髓抑制的总疗程数(43、32个)明显多于动脉组(23、17个)(P＜0.01).结论 不同途径新辅助化疗治疗LACC的近期疗效相当,静脉给药操作简单,但不良反应相对较大,有条件时以选择动脉途径新辅助化疗治疗为好.
目的 對比分析靜脈和動脈不同給藥途徑新輔助化療治療跼部晚期宮頸癌(LACC)的臨床療效和不良反應.方法 對宮頸腫瘤直徑≥4 cm、國際婦產科聯盟(FIGO)分期Ⅰ B～ⅡB期的LACC患者分彆採用靜脈途徑化療(靜脈組,36例)和動脈途徑化療(動脈組,34例),觀察併比較其化療效果、不良反應等.結果 兩組患者54例穫得近期部分緩解,總有效率為77.1%(54/70),其中靜脈組為72.2%(26/36),動脈組為82.4%(28/34),兩組比較差異無統計學意義(P＞0.05).靜脈組髮生的胃腸道反應、骨髓抑製的總療程數(43、32箇)明顯多于動脈組(23、17箇)(P＜0.01).結論 不同途徑新輔助化療治療LACC的近期療效相噹,靜脈給藥操作簡單,但不良反應相對較大,有條件時以選擇動脈途徑新輔助化療治療為好.
목적 대비분석정맥화동맥불동급약도경신보조화료치료국부만기궁경암(LACC)적림상료효화불량반응.방법 대궁경종류직경≥4 cm、국제부산과련맹(FIGO)분기Ⅰ B～ⅡB기적LACC환자분별채용정맥도경화료(정맥조,36례)화동맥도경화료(동맥조,34례),관찰병비교기화료효과、불량반응등.결과 량조환자54례획득근기부분완해,총유효솔위77.1%(54/70),기중정맥조위72.2%(26/36),동맥조위82.4%(28/34),량조비교차이무통계학의의(P＞0.05).정맥조발생적위장도반응、골수억제적총료정수(43、32개)명현다우동맥조(23、17개)(P＜0.01).결론 불동도경신보조화료치료LACC적근기료효상당,정맥급약조작간단,단불량반응상대교대,유조건시이선택동맥도경신보조화료치료위호.
Objective To compare the efficacy and toxicity of neoadjuvant chemotherapy with venous and arterial way in patients with locally advanced cervical cancer( LACC ). Methods A retrospective study was carried out on 70 patients suffering from tumor diameter≥4 cm and FIGO stage Ⅰ B- Ⅱ B disease of LACC. Among 70 patients, 36 were given venous chemotherapy ( venous group ) and 34 were given arterial interventional chemotherapy(arterial group). All patients received platinum-based neoadjuvant chemotherapy.The therapeutic toxic and adverse effects of the two groups were analyzed and compared. Results Clinical response to neoadjuvant chemotherapy occurred in 54 patients with a total effective rate of 77.1% (54/70),that of venous group was 72.2% (26/36) and that of arterial group was 82.4% (28/34),there was no significant difference between two groups (P ＞ 0.05 ). The number of the occurrence of gastrointestinal tract reaction and bone marrow depression in venous group (43,32 pieces) was more than that in arterial group (23,17 pieces)(P ＜ 0.01 ). Conclusion The results suggest that the therapeutic effects of venous and arterial interventional chemotherapy be similar,but the adverse effects of venous chemotherapy is more serious than that of arterial interventional chemotherapy.
