中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2011年
4期
249-251
,共3页
红斑狼疮,系统性%巨细胞病毒感染%糖皮质激素
紅斑狼瘡,繫統性%巨細胞病毒感染%糖皮質激素
홍반랑창,계통성%거세포병독감염%당피질격소
Lupus erythematosus,systemic%Cytomegalovirus infection%Corticosteroid
目的 探讨系统性红斑狼疮(SLE)合并巨细胞病毒(CMV)感染的临床表现.方法 分析SLE合并CMV感染患者的相关临床资料,进行统计分析.结果 2221例SLE住院患者中,合并CMV活动性感染121例,发生率为5.4%.发热98例占81%,其中80例(66.1%)以发热为唯一表现,肝功能损害8例、呼吸道症状5例、血液系统异常4例、心肌炎和脑病各1例,分别占6.6%、4.1%、3.3%、0.8%、0.8%;另22例(18.2%)不明原因原发病活动而经检查发现CMV感染.75.2%患者SLE疾病活动指数达10分以上.121例中,4例死亡,6例放弃治疗.其余患者CMV感染均于治疗2～4周[(15±6)d]得到控制.结论 CMV感染是SLE的常见合并症,临床表现无特征性,对不明原因发热者应及时做CMV的相关检查以利诊断.
目的 探討繫統性紅斑狼瘡(SLE)閤併巨細胞病毒(CMV)感染的臨床錶現.方法 分析SLE閤併CMV感染患者的相關臨床資料,進行統計分析.結果 2221例SLE住院患者中,閤併CMV活動性感染121例,髮生率為5.4%.髮熱98例佔81%,其中80例(66.1%)以髮熱為唯一錶現,肝功能損害8例、呼吸道癥狀5例、血液繫統異常4例、心肌炎和腦病各1例,分彆佔6.6%、4.1%、3.3%、0.8%、0.8%;另22例(18.2%)不明原因原髮病活動而經檢查髮現CMV感染.75.2%患者SLE疾病活動指數達10分以上.121例中,4例死亡,6例放棄治療.其餘患者CMV感染均于治療2～4週[(15±6)d]得到控製.結論 CMV感染是SLE的常見閤併癥,臨床錶現無特徵性,對不明原因髮熱者應及時做CMV的相關檢查以利診斷.
목적 탐토계통성홍반랑창(SLE)합병거세포병독(CMV)감염적림상표현.방법 분석SLE합병CMV감염환자적상관림상자료,진행통계분석.결과 2221례SLE주원환자중,합병CMV활동성감염121례,발생솔위5.4%.발열98례점81%,기중80례(66.1%)이발열위유일표현,간공능손해8례、호흡도증상5례、혈액계통이상4례、심기염화뇌병각1례,분별점6.6%、4.1%、3.3%、0.8%、0.8%;령22례(18.2%)불명원인원발병활동이경검사발현CMV감염.75.2%환자SLE질병활동지수체10분이상.121례중,4례사망,6례방기치료.기여환자CMV감염균우치료2～4주[(15±6)d]득도공제.결론 CMV감염시SLE적상견합병증,림상표현무특정성,대불명원인발열자응급시주CMV적상관검사이리진단.
Objective To investigate the clinical manifestations of cytomegalovirus (CMV) infection in patients with systemic lupus erythematosus (SLE). Methods Data of the consecutive cases of SLE complicated with active CMV infection including clinical manifestations, SLEDAI score, dosage of corticosteroid and immunosuppressants used for treatment,radiological and laboratory examinations were collected and analyzed.Results Among 2221 consecutive patients of SLE, 5.4%(121 cases) were diagnosed to be complicated with active CMV infection. Fever was the most common symptom, followed by serious liver function damage,respiratory symptoms,hematological abnormalities, myocarditis, and encephalopathy, accounted for 81%(98cases), 6.6%(8 cases), 4.1%(5 cases), 3.3%(4 cases), 0.8%(1 case), and 0.8%(1 case)respectively; in addition, 22 (18.2%) cases had no symptom. SLEDAI was higher than 15 in 47.1% cases, and 10-14 in 28.1% cases. 81% of patients were treated with corticosteroid, and 55.4% were treated with immunosuppressants. Ganciclovir was given once the diagnosis of active CMV infection was established. In most of the patients, active CMV infection had been controlled within 14-28 days, except 4 died and 6 gave up the therapy. Conclusion SLE with active CMV infection is common,especially in patients who are treated with corticosteroid and/or immunosuppressants. Clinical manifestations of SLE complicated with active CMV infection are generally nonspecific.In patients with unexplained fever,or liver damage,or lung disease,or active SLE patients who have no symptom but are refractory to the treatment, CMV infection should be suspected and the relevant laboratory tests should be ordered for early diagnosis and treatment.
