中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2011年
5期
529-532
,共4页
吴新民%于布为%薛张纲%刘斌%熊利泽%薛昀%李敏%陶国荣%李茜%杨笛%路志红
吳新民%于佈為%薛張綱%劉斌%熊利澤%薛昀%李敏%陶國榮%李茜%楊笛%路誌紅
오신민%우포위%설장강%류빈%웅리택%설윤%리민%도국영%리천%양적%로지홍
雄甾烷醇类%神经肌肉阻滞%剂量效应关系,药物%血液循环
雄甾烷醇類%神經肌肉阻滯%劑量效應關繫,藥物%血液循環
웅치완순류%신경기육조체%제량효응관계,약물%혈액순배
Androstanols%Neuromuscular blockade%Dose-response relationship,drug%Blood circulation
目的 比较国产和进口罗库溴铵的药效学及对循环功能的影响.方法 择期全麻手术患者210例,年龄18～65岁,ASA分级Ⅰ或Ⅱ级.采用随机数字表法,将患者随机分为2组(n=105):国产罗库溴铵组(Ⅰ组)和进口罗库溴铵组(Ⅱ组).采用TOF-Wateh(R) SX型加速度肌松监测仪刺激尺神经,观察拇内收肌颤搐情况.记录静脉注射插管剂量(0.6 mg/kg)的罗库溴铵后气管插管条件、肌松起效时间、临床作用时间、最大肌颤搐抑制程度、75%恢复时间、恢复指数、循环指标完全恢复时间、血液动力学指标及不良事件的发生情况.结果 两组肌松起效时间、临床作用时间、恢复指数、肌颤搐最大抑制程度、气管插管条件、循环指标完全恢复时间、给肌松药前后血液动力学指标及不良事件发生率比较差异无统计学意义(P＞0.05),Ⅱ组75%恢复时间长于Ⅰ组(P＜0.05).结论 国产罗库溴铵与进口罗库溴铵具有相似的药效学特性,对循环功能无明显不利影响.
目的 比較國產和進口囉庫溴銨的藥效學及對循環功能的影響.方法 擇期全痳手術患者210例,年齡18～65歲,ASA分級Ⅰ或Ⅱ級.採用隨機數字錶法,將患者隨機分為2組(n=105):國產囉庫溴銨組(Ⅰ組)和進口囉庫溴銨組(Ⅱ組).採用TOF-Wateh(R) SX型加速度肌鬆鑑測儀刺激呎神經,觀察拇內收肌顫搐情況.記錄靜脈註射插管劑量(0.6 mg/kg)的囉庫溴銨後氣管插管條件、肌鬆起效時間、臨床作用時間、最大肌顫搐抑製程度、75%恢複時間、恢複指數、循環指標完全恢複時間、血液動力學指標及不良事件的髮生情況.結果 兩組肌鬆起效時間、臨床作用時間、恢複指數、肌顫搐最大抑製程度、氣管插管條件、循環指標完全恢複時間、給肌鬆藥前後血液動力學指標及不良事件髮生率比較差異無統計學意義(P＞0.05),Ⅱ組75%恢複時間長于Ⅰ組(P＜0.05).結論 國產囉庫溴銨與進口囉庫溴銨具有相似的藥效學特性,對循環功能無明顯不利影響.
목적 비교국산화진구라고추안적약효학급대순배공능적영향.방법 택기전마수술환자210례,년령18～65세,ASA분급Ⅰ혹Ⅱ급.채용수궤수자표법,장환자수궤분위2조(n=105):국산라고추안조(Ⅰ조)화진구라고추안조(Ⅱ조).채용TOF-Wateh(R) SX형가속도기송감측의자격척신경,관찰무내수기전휵정황.기록정맥주사삽관제량(0.6 mg/kg)적라고추안후기관삽관조건、기송기효시간、림상작용시간、최대기전휵억제정도、75%회복시간、회복지수、순배지표완전회복시간、혈액동역학지표급불량사건적발생정황.결과 량조기송기효시간、림상작용시간、회복지수、기전휵최대억제정도、기관삽관조건、순배지표완전회복시간、급기송약전후혈액동역학지표급불량사건발생솔비교차이무통계학의의(P＞0.05),Ⅱ조75%회복시간장우Ⅰ조(P＜0.05).결론 국산라고추안여진구라고추안구유상사적약효학특성,대순배공능무명현불리영향.
Objective To compare the phaimacodynamics and circulatory function of domestic and imported rocuronium. Methods This is a five center study of rocuronium. Two hundred and ten ASA Ⅰ or Ⅱ patients aged 18-65 yr undergoing elective surgery under general anesthesia were randomly divided into 2 groups (n = 105 each): domestic rocuronium group (group Ⅰ ) and imported rocuronium group (group Ⅱ ) . Anesthesia was induced and maintained with TCI of propofol (target plasma concentration = 3 mg/L) and remifentanil (target effect-site concentration = 2-4 μg/L) . Tracheal intubation was facilitated with intravenous rocuronium 0.6 mg/kg. The N-M function was assessed by accelerography (TOF-Watch(R) SX, Organon, Netherlands) using TOF stimulation of ulnar nerve. Onset time, clinical duration, 75% recovery time,recovery indexes, the extent of maximal NM blockade and intubation conditions (ease of laryngoscopy, position of vocal cords and airway reaction) were monitored and recorded. BP and HR were also recorded. Results There were no significant differences in the onset time, clinical duration, recovery indexes, the extent of maximal N-M blockade, the intubation conditions, BP, HR and adverse reactions between groups Ⅰ and Ⅱ ( P ＞ 0.05) . The 75% recovery time was significantly longer in group Ⅱ than in group Ⅰ (P ＜ 0.05＝. Conclusion The pharmacodynamics of domestic and imported rocuronium is comparable. The two drugs have no adverse effect on the circulatory function.
