中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
13期
36-39
,共4页
高血压%危险因素%靶器官损害
高血壓%危險因素%靶器官損害
고혈압%위험인소%파기관손해
Hypertension%Risk factors%Target organ damage
目的 探讨高血压前期人群靶器官损害情况.方法 选择健康体检人群中278例高血压前期者(高血压前期组)和136例血压正常者(血压正常组)作为研究对象,分别测量血压、身高、体重、腰围及生化指标[包括血肌酐(SCr)、血尿素氮(BUN)、尿酸(UA)、空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及晨尿白蛋白].进行心脏扇扫、颈部血管超声检查,测量左室舒张末期内径(LVEDd),左室后壁厚度(LVPWT),室间隔厚度(IVST).颈动脉内膜-中层厚度(IMT)、斑块指数(PI),统计斑块发生率,根据公式计算左室心肌质量指数(LVMI)、相对室壁厚度(RWT)、肾小球滤过率(GFR)、体质指数(BMI),并进行比较.结果 高血压前期组合并≥1个、≥12个及≥3个危险因素的比例分别为71.9%(200/278)、40.6%(113/278)、13.7%(38/278),而血压正常组分别为30.1%(41/136)、13.2%(18/136)、5.9%(8/136),两组比较差异均有统计学意义(P＜0.05).与血压正常组比较,高血压前期组年龄、收缩压、舒张压、FBG、腰围、BMI、晨尿白蛋白、TG、TC、UA、LDL-C、IVST、LVPWT、RWT、LVMI、IMT、PI升高,左室向心性重构率、向心性肥厚率、离心性肥厚率及颈动脉斑块发生率升高,左室正常构型率及GFR下降(P＜0.01或＜0.05).结论 高血压前期人群与血压正常人群相比伴随心血管危险因素增多,靶器官损害发生率明显增加.
目的 探討高血壓前期人群靶器官損害情況.方法 選擇健康體檢人群中278例高血壓前期者(高血壓前期組)和136例血壓正常者(血壓正常組)作為研究對象,分彆測量血壓、身高、體重、腰圍及生化指標[包括血肌酐(SCr)、血尿素氮(BUN)、尿痠(UA)、空腹血糖(FBG)、總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)及晨尿白蛋白].進行心髒扇掃、頸部血管超聲檢查,測量左室舒張末期內徑(LVEDd),左室後壁厚度(LVPWT),室間隔厚度(IVST).頸動脈內膜-中層厚度(IMT)、斑塊指數(PI),統計斑塊髮生率,根據公式計算左室心肌質量指數(LVMI)、相對室壁厚度(RWT)、腎小毬濾過率(GFR)、體質指數(BMI),併進行比較.結果 高血壓前期組閤併≥1箇、≥12箇及≥3箇危險因素的比例分彆為71.9%(200/278)、40.6%(113/278)、13.7%(38/278),而血壓正常組分彆為30.1%(41/136)、13.2%(18/136)、5.9%(8/136),兩組比較差異均有統計學意義(P＜0.05).與血壓正常組比較,高血壓前期組年齡、收縮壓、舒張壓、FBG、腰圍、BMI、晨尿白蛋白、TG、TC、UA、LDL-C、IVST、LVPWT、RWT、LVMI、IMT、PI升高,左室嚮心性重構率、嚮心性肥厚率、離心性肥厚率及頸動脈斑塊髮生率升高,左室正常構型率及GFR下降(P＜0.01或＜0.05).結論 高血壓前期人群與血壓正常人群相比伴隨心血管危險因素增多,靶器官損害髮生率明顯增加.
목적 탐토고혈압전기인군파기관손해정황.방법 선택건강체검인군중278례고혈압전기자(고혈압전기조)화136례혈압정상자(혈압정상조)작위연구대상,분별측량혈압、신고、체중、요위급생화지표[포괄혈기항(SCr)、혈뇨소담(BUN)、뇨산(UA)、공복혈당(FBG)、총담고순(TC)、삼선감유(TG)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)급신뇨백단백].진행심장선소、경부혈관초성검사,측량좌실서장말기내경(LVEDd),좌실후벽후도(LVPWT),실간격후도(IVST).경동맥내막-중층후도(IMT)、반괴지수(PI),통계반괴발생솔,근거공식계산좌실심기질량지수(LVMI)、상대실벽후도(RWT)、신소구려과솔(GFR)、체질지수(BMI),병진행비교.결과 고혈압전기조합병≥1개、≥12개급≥3개위험인소적비례분별위71.9%(200/278)、40.6%(113/278)、13.7%(38/278),이혈압정상조분별위30.1%(41/136)、13.2%(18/136)、5.9%(8/136),량조비교차이균유통계학의의(P＜0.05).여혈압정상조비교,고혈압전기조년령、수축압、서장압、FBG、요위、BMI、신뇨백단백、TG、TC、UA、LDL-C、IVST、LVPWT、RWT、LVMI、IMT、PI승고,좌실향심성중구솔、향심성비후솔、리심성비후솔급경동맥반괴발생솔승고,좌실정상구형솔급GFR하강(P＜0.01혹＜0.05).결론 고혈압전기인군여혈압정상인군상비반수심혈관위험인소증다,파기관손해발생솔명현증가.
Objective To investigate the incidence of target organ damage in prehypertensive. Methods Two hundred and seventy-eight prehypertensive cases (prehypertensive group) and 136 normotensive cases(normotensive group) were involved in this study. The blood pressure,body height,weight and waist circumference were measured. Serum creatinine (SCr), urea nitrogen (BUN),uric acid(UA), fasting blood glucose (FBG), total cholesterol (TC), triglyceride(TG),low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and morning urine albumin concentration were detected by automatic biochemical analyzer. Left ventricular end-diastolic dimension (LVEDd), left ventricular posterior wall thickness (LVPWT), interventricular septal thickness (IVST), intima-media thickness (IMT) and plaque index (PI) were examined by ultrasonography. The incidence rates of plaque, left ventricular mass index (LVMI), relative wall thickness (RWT), glomerular filtration rate (GFR) and body mass index (BMI) were calculated. Results The proportion of ≥ 1, ≥2 and ≥3 kinds of risk factors was 71.9% (200/278),40.6%(113/278) and 13.7%(38/278) in prehypertensive group and 30.1%(41/136), 13.2% (18/136) and 5.9%(8/136) in normotensive group, and there was significant difference between the two groups (P＜0.05). Compared with normotensive group, the age,systolic pressure, diastolic pressure, FBG, waist, BMI, morning urine albumin, TG,TC,UA,LDL-C,IVST,LVPWT,RWT,LVMI,IMT,PI were higher, meanwhile the incidence rate of concentric reconstruction of left ventricular, concentric hypertrophy, eccentric hypertrophy and carotid plaque was higher, and the incidence rate of left ventricular normal configuration and GFR was lower (P＜0.01 or ＜0.05). Conclusion People with prehypertensive may accompany with many kinds of cardiovascular risk factors, and the incidence rate of target organ damage is significantly increased.
