CAJ | 학술논문

目的通过对上海市某医院产妇乳汁中多溴联苯醚(PBDEs)含量的测定和分析,了解该地区人群中PBDEs的暴露水平及其相关影响因素.方法于2006年9月至2007年4月在上海市某医院对48名产妇进行问卷调查,并采集其乳汁样本,产妇均为单胎妊娠,排除高血压、糖尿病、HIV感染和不良用药史.采用气相色谱-负化学电离源-质谱法测定乳汁中7种PBDE同族体[溴代联苯醚(BDE)-28,BDE-47,BDE-100,BDE-99,BDE-154,BDE-153和BDE-183]的含量,并分析其影响因素.结果产妇乳汁中7种PBDEs(∑,PBDEs)浓度中位数为8.81 ng/g脂重(lipid weight,1w),浓度范围为1.92-41.55 ng/g 1w.BDE-28、BDE-47、BDE-100、BDE-99、BDE-154、BDE-153、BDE-183检出率分别为98%(47/48)、96%(46/48)、86%(41/48)、90%(43/48)、83%(40/48)、98%(47/48)、90%(43/48);浓度中位数分别为0.88、0.99、0.97、1.39、1.14、2.17、1.41 ng/g 1w.不同学历产妇乳汁中PBDEs水平(logΣ7PBDEs)分别为:初中及以下为(0.89±0.24)、高中为(1.02±0.17)、大专及以上为(1.08±0.28);不同月收入水平产妇乳汁中PBDEs水平(log∑7PBDEs)分别为:＜1000元为(0.89±0.12)、1000-3000元为(1.01±0.24)、＞3000元为(1.13±0.21).相关分析发现母亲受教育水平(r=0.322,P＜0.05)和收入水平(r=0.388,P＜0.05)与母乳PBDEs暴露水平呈正相关.结论产妇乳汁中普遍含有PBDEs,母亲受教育水平和收入水平可能影响母乳中PBDEs水平.
목적 통과대상해시모의원산부유즙중다추련분미(PBDEs)함량적측정화분석,료해해지구인군중PBDEs적폭로수평급기상관영향인소.방법 우2006년9월지2007년4월재상해시모의원대48명산부진행문권조사,병채집기유즙양본,산부균위단태임신,배제고혈압、당뇨병、HIV감염화불량용약사.채용기상색보-부화학전리원-질보법측정유즙중7충PBDE동족체[추대련분미(BDE)-28,BDE-47,BDE-100,BDE-99,BDE-154,BDE-153화BDE-183]적함량,병분석기영향인소.결과 산부유즙중7충PBDEs(∑,PBDEs)농도중위수위8.81 ng/g지중(lipid weight,1w),농도범위위1.92-41.55 ng/g 1w.BDE-28、BDE-47、BDE-100、BDE-99、BDE-154、BDE-153、BDE-183검출솔분별위98%(47/48)、96%(46/48)、86%(41/48)、90%(43/48)、83%(40/48)、98%(47/48)、90%(43/48);농도중위수분별위0.88、0.99、0.97、1.39、1.14、2.17、1.41 ng/g 1w.불동학력산부유즙중PBDEs수평(logΣ7PBDEs)분별위:초중급이하위(0.89±0.24)、고중위(1.02±0.17)、대전급이상위(1.08±0.28);불동월수입수평산부유즙중PBDEs수평(log∑7PBDEs)분별위:＜1000원위(0.89±0.12)、1000-3000원위(1.01±0.24)、＞3000원위(1.13±0.21).상관분석발현모친수교육수평(r=0.322,P＜0.05)화수입수평(r=0.388,P＜0.05)여모유PBDEs폭로수평정정상관.결론 산부유즙중보편함유PBDEs,모친수교육수평화수입수평가능영향모유중PBDEs수평.
Objective To measure the concentration of polybrominated diphenyl ethers(PBDEs)in human breast milk from a hospital in Shanghai and analyze the influencing factors.Methods Forty-eight puerperas from a hospital in Shanghai were selected to answer a questionnaire.and their breast milk samples were collected from September 2006 to April 2007.All the puerperas were singleton pregnancies.excluding high blood pressure.diabetes,HIV infection and adverse medical history.Seven congenera(BDE-28,BDE47,BDE-100,BDE-99,BDE-154,BDE-153 and BDE-183)were measured by gas chromatography-negative chemical ionization-mass spectrometry and the influencing factors were analyzed.Results The median of total PBDEs concentration in breast milk was 8.81 ng/g lipid weight(1w),and the range was 1.92-41.55,,g/g 1W. The detection rates of seven congeners(BDE-28,BDE-47,BDE-100,BDE-99,BDE-154,BDE-153,BDE-183)were 98%(47/48),96%(46/48),86%(41/48),90%(43/48),83%(40/48),98%(47/48),90%(43/48),and the median of them was,0.88,0.99,0.97,1.39,1.14,2.17,1.41 ng/g 1w,respectively.LogΣ7PBDEs in breast milk from mothers with different education levels were divided into junior high school or lower(0.89 ±0.24),senior high school(1.02±0.17),junior college or higher(1.08±0.28).LogΣ7PBDEs in breast milk from mothers with different income levels were divided as ＜1000 yuan(0.89±0.12),1000-3000 yuan(1.01±0.24),＞3000 yuan(1.13±0.21).Correlation analysis showed that both the mothers'education level(r=0.322.P＜0.05)and income level(r=0.388.P＜0.05)have a positive correlation to PBDEs levels in breast milk. Conclusion It is very common to detect PBDEs in human breast-milk.however,the education and income levels of the mothers my be the influencing factors.