中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2010年
5期
506-511
,共6页
马龙%程广辉%王慧%黎莉%龚瑶琴%刘奇迹
馬龍%程廣輝%王慧%黎莉%龔瑤琴%劉奇跡
마룡%정엄휘%왕혜%려리%공요금%류기적
ABCG1基因%冠状动脉粥样硬化性心脏病%关联研究%单核甘酸多态性%中国汉族
ABCG1基因%冠狀動脈粥樣硬化性心髒病%關聯研究%單覈甘痠多態性%中國漢族
ABCG1기인%관상동맥죽양경화성심장병%관련연구%단핵감산다태성%중국한족
ABCG1 gene%coronary atherosclerotic disease%association study%single nucleotide polymorphism%Chinese Han
目的 应用基于群体的病例-对照关联研究方法探讨ABCG1基因上的遗传多态性与冠状动脉粥样硬化性心脏病(简称冠心病)及病情严重程度的相关性.方法 在山东汉族人群中收集541例冠心病患者和649名正常对照,采用聚合酶链反应-限制性片段长度多态方法对ABCG1基因内两个单核甘酸多态位点进行基因分型,统计学分析.结果 rs225374等位基因C在病例组中的频率显著高于对照组(OR=1.186,95%CI:1.009～1.394,P=O.039),在男性病例组与对照组中的差异同样具有统计学意义(OR=1.236,95%CI:1.014～1.506,P=O.036).rs1044317等位基因A在病例组中的频率显著高于对照组(OR=1.187,95%CI:1.009～1.397,P=0.039).单独在病例组内的分析结果显示,rs225374等位基因C频率在高Gensini积分组中显著高于低Gensini积分组(OR=1.303,95%CI:1.024～1.657,P=O.031).结论 ABCG1基因上两个单核苷酸多态位点与冠心病易感性及病情严重程度具有一定相关性.
目的 應用基于群體的病例-對照關聯研究方法探討ABCG1基因上的遺傳多態性與冠狀動脈粥樣硬化性心髒病(簡稱冠心病)及病情嚴重程度的相關性.方法 在山東漢族人群中收集541例冠心病患者和649名正常對照,採用聚閤酶鏈反應-限製性片段長度多態方法對ABCG1基因內兩箇單覈甘痠多態位點進行基因分型,統計學分析.結果 rs225374等位基因C在病例組中的頻率顯著高于對照組(OR=1.186,95%CI:1.009～1.394,P=O.039),在男性病例組與對照組中的差異同樣具有統計學意義(OR=1.236,95%CI:1.014～1.506,P=O.036).rs1044317等位基因A在病例組中的頻率顯著高于對照組(OR=1.187,95%CI:1.009～1.397,P=0.039).單獨在病例組內的分析結果顯示,rs225374等位基因C頻率在高Gensini積分組中顯著高于低Gensini積分組(OR=1.303,95%CI:1.024～1.657,P=O.031).結論 ABCG1基因上兩箇單覈苷痠多態位點與冠心病易感性及病情嚴重程度具有一定相關性.
목적 응용기우군체적병례-대조관련연구방법탐토ABCG1기인상적유전다태성여관상동맥죽양경화성심장병(간칭관심병)급병정엄중정도적상관성.방법 재산동한족인군중수집541례관심병환자화649명정상대조,채용취합매련반응-한제성편단장도다태방법대ABCG1기인내량개단핵감산다태위점진행기인분형,통계학분석.결과 rs225374등위기인C재병례조중적빈솔현저고우대조조(OR=1.186,95%CI:1.009～1.394,P=O.039),재남성병례조여대조조중적차이동양구유통계학의의(OR=1.236,95%CI:1.014～1.506,P=O.036).rs1044317등위기인A재병례조중적빈솔현저고우대조조(OR=1.187,95%CI:1.009～1.397,P=0.039).단독재병례조내적분석결과현시,rs225374등위기인C빈솔재고Gensini적분조중현저고우저Gensini적분조(OR=1.303,95%CI:1.024～1.657,P=O.031).결론 ABCG1기인상량개단핵감산다태위점여관심병역감성급병정엄중정도구유일정상관성.
Objective To investigate the association of the ATP-binding cassette sub-family G member 1 (ABCG1)gene polymorphisms with coronary atherosclerotic disease (CAD) in Chinese Han population. Methods A population based case-control association study was carried out in 541 patients with CAD and 649 healthy controls from Chinese Han population. Two single nucleotide polymorphisms (SNPs) of the ABCG1 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Logistic regression was used to compare the genotypic and allelic frequency difference.Results The frequency of allele C of rs225374 was significantly higher in the CAD patients than that in the healthy controls (OR= 1. 186, 95 %CI: 1. 009-1. 394, P=0. 039), while the difference was also significant in the male subgroup (OR= 1. 236, 95 %CI: 1. 014-1. 506, P = 0. 036). A statistically higher frequency of rs1044317 allele A was found in the CAD patients in comparison to the healthy controls (OR= 1. 187, 95%CI: 1. 009-1. 397, P=0.039). In case-only association study, rs225374 showed significant association in the high Gensini score group compared with the low Gensini score group (OR= 1. 303, 95%CI: 1. 024-1. 657,P=0. 031). Conclusion The two SNPs of the ABCG1 gene might be associated with the susceptibility and severity of CAD in Chinese Han population.
