时珍国医国药
時珍國醫國藥
시진국의국약
LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH
2009年
11期
2752-2753
,共2页
黄芩%黄芩苷%小鼠%肝损伤
黃芩%黃芩苷%小鼠%肝損傷
황금%황금감%소서%간손상
Scutellaria baicalensis Georgi%Baicalin%Mice%Liver injury
目的 研究黄芩苷对小鼠急性肝损伤的保护作用.方法 给动物灌胃给药,用CCl_4、D-半乳糖制作小鼠急性肝损伤模型,用比色分析法测定小鼠血清天冬氨酸转氨酶(aspartate transaminase, ALT)、丙氨酸转氨酶(alanine transaminase, AST)的活性;测定小鼠血清超氧化物歧化酶(superoxide dismutase, SOD)、谷胱甘肽过氧化物酶(glutathione perioxidase, GSH-Px)的活性及丙二醛(malondialdehyde, MDA)的含量.结果 黄芩苷能显著降低因CCl_4、D-半乳糖所致急性肝损伤小鼠血清ALT,AST的升高;对急性肝损伤小鼠血清SOD、GSH-Px的活性有明显的升高作用及降低MDA的含量.结论 黄芩苷对CCl_4、D-半乳糖所致小鼠急性肝损伤有保护作用.
目的 研究黃芩苷對小鼠急性肝損傷的保護作用.方法 給動物灌胃給藥,用CCl_4、D-半乳糖製作小鼠急性肝損傷模型,用比色分析法測定小鼠血清天鼕氨痠轉氨酶(aspartate transaminase, ALT)、丙氨痠轉氨酶(alanine transaminase, AST)的活性;測定小鼠血清超氧化物歧化酶(superoxide dismutase, SOD)、穀胱甘肽過氧化物酶(glutathione perioxidase, GSH-Px)的活性及丙二醛(malondialdehyde, MDA)的含量.結果 黃芩苷能顯著降低因CCl_4、D-半乳糖所緻急性肝損傷小鼠血清ALT,AST的升高;對急性肝損傷小鼠血清SOD、GSH-Px的活性有明顯的升高作用及降低MDA的含量.結論 黃芩苷對CCl_4、D-半乳糖所緻小鼠急性肝損傷有保護作用.
목적 연구황금감대소서급성간손상적보호작용.방법 급동물관위급약,용CCl_4、D-반유당제작소서급성간손상모형,용비색분석법측정소서혈청천동안산전안매(aspartate transaminase, ALT)、병안산전안매(alanine transaminase, AST)적활성;측정소서혈청초양화물기화매(superoxide dismutase, SOD)、곡광감태과양화물매(glutathione perioxidase, GSH-Px)적활성급병이철(malondialdehyde, MDA)적함량.결과 황금감능현저강저인CCl_4、D-반유당소치급성간손상소서혈청ALT,AST적승고;대급성간손상소서혈청SOD、GSH-Px적활성유명현적승고작용급강저MDA적함량.결론 황금감대CCl_4、D-반유당소치소서급성간손상유보호작용.
Objective To study the protective effects of baicalin extract against acute liver injury in mice. Methods Baicalin was perfused stomache to the mice with liver injury by carton tetrachloride and D - galactoasmine. The activities of aspartate transami-nase ( AST) , alanine transaminase ( ALT) , superoxide dismutase (SOD) , glutathione perioxidase (GSH - Px) ; and the content of raalondialdehyde (MDA) in serum were investigated using colorimetric method. Results Baicalin significantly reduced acute liver injury induced by carton tetrachloride and D -galactoasmine, by means of decreasing ALT and AST in serum; the activities of SOD, GSH - Px in treat group were higher than that of model group and the content of MDA in treat group was lower than that of model group, respectively. Conclusion Baicalin has protective effects on mice with acute hepatic injury induced by carton tetrachloride and D - galactoasmine.
