国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2009年
2期
152-156
,共5页
Survivin%细胞凋亡%基因治疗
Survivin%細胞凋亡%基因治療
Survivin%세포조망%기인치료
Survivin%Cell apoptosis%Gene therapy
Survivin是凋亡抑制蛋白家族(IAPs)的新成员,在人类多种肿瘤组织中高度表达,而在分化成熟的组织中一般不表达或低表达.Survivin是迄今发现的最强的凋亡抑制因子,不仅具有调控细胞凋亡和细胞周期的双重功能,而且可促进细胞转化并且参与细胞的有丝分裂、血管的生成和肿瘤细胞放化疗抵抗性的产生等.
Survivin是凋亡抑製蛋白傢族(IAPs)的新成員,在人類多種腫瘤組織中高度錶達,而在分化成熟的組織中一般不錶達或低錶達.Survivin是迄今髮現的最彊的凋亡抑製因子,不僅具有調控細胞凋亡和細胞週期的雙重功能,而且可促進細胞轉化併且參與細胞的有絲分裂、血管的生成和腫瘤細胞放化療牴抗性的產生等.
Survivin시조망억제단백가족(IAPs)적신성원,재인류다충종류조직중고도표체,이재분화성숙적조직중일반불표체혹저표체.Survivin시흘금발현적최강적조망억제인자,불부구유조공세포조망화세포주기적쌍중공능,이차가촉진세포전화병차삼여세포적유사분렬、혈관적생성화종류세포방화료저항성적산생등.
Survivin is a new member belonging to the inhibition of apoptosis proteins(IAPs), that is strongly expressed in the vast majority of human neoplasms but not or just at a low level in terminally differentiated tis-sues. It is the most powerful inhibition of apoptosis at present. Survivin regulates both cell apoptosis and cell cycle progression. In addition, it appears to be involved in cell transformation, mitosis, vasculogenesis, tumorcells'radiotherapy and chemotherapy resistance and so forth.
