CAJ | 학술논문

目的探讨神经生长因子(NGF)对脑外伤后的人格改变的影响及治疗效果.方法选取2006年4月1日至2008年9月1日本院脑外伤住院患者(入院时GCS评分10～12)的39例,按入院顺序完全随机分为对照组(19例)和治疗组(20例).对照组以维生素B1、B12和高压氧等常规治疗并,并给予生理盐水2ml作空白对照;治疗组在常规治疗基础上,以神经生长因子(NGF)剂量为6000U/日,每日肌注1次.两组均以28天为一个疗程,期间观察其意识状态和肝肾功能变化.一疗程后通过症状自评量表(SCL-90)、艾森克人格问卷(EPQ)等对人格改变因素进行临床研究.结果两组神经功能变化无明显差异;与对照组比较,治疗组心理、人格水平显著改善(P<0.05);症状自评量表(SCL-90)大部分因子得分高于对照组(P<0.05).结论神经生长因子(NGF)对脑外伤后出现心理和人格变化有一定治疗作用.
목적 탐토신경생장인자(NGF)대뇌외상후적인격개변적영향급치료효과.방법 선취2006년4월1일지2008년9월1일본원뇌외상주원환자(입원시GCS평분10～12)적39례,안입원순서완전수궤분위대조조(19례)화치료조(20례).대조조이유생소B1、B12화고압양등상규치료병,병급여생리염수2ml작공백대조;치료조재상규치료기출상,이신경생장인자(NGF)제량위6000U/일,매일기주1차.량조균이28천위일개료정,기간관찰기의식상태화간신공능변화.일료정후통과증상자평량표(SCL-90)、애삼극인격문권(EPQ)등대인격개변인소진행림상연구.결과 량조신경공능변화무명현차이;여대조조비교,치료조심리、인격수평현저개선(P<0.05);증상자평량표(SCL-90)대부분인자득분고우대조조(P<0.05).결론 신경생장인자(NGF)대뇌외상후출현심리화인격변화유일정치료작용.
Objective To explore the effect of nerve growth factor (NGF) on personality disorders after cerebral trauma. Methods 39 inpatients (Glasgow coma scale, GCS10～12) with cerebral injury were dividedinto two groups. The patients in control group (n=19) was given conventional therapy such as vitamineB1, vitamineB12 and high pressure oxygen; the patients in study group (n=11) was given NGF 6000U/d intramuscularly for 28 days. During the treatment, liver and kidney function were monitored continually and GCS were measured. Personality disorders of patients were assessed with SCL-90 and EPQ analysis. Results There was no difference in GCS between two groups. Compared with the control group, there was a significant improvement in psychology and personality in study group. Conclusions Nerve growth factor (NGF) is effective in the treatment of brain injury.