国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2011年
1期
64-66
,共3页
基因,SALL4%肿瘤%白血病%干细胞
基因,SALL4%腫瘤%白血病%榦細胞
기인,SALL4%종류%백혈병%간세포
Genes,SALL4%Neoplasms%Leukemia%Stem cells
SALL4与造血系统恶性肿瘤的发生有密切关系.深入研究SALL4基因及蛋白的功能,将有助于阐明白血病的发病机制,为治疗白血病提供新靶点.
SALL4與造血繫統噁性腫瘤的髮生有密切關繫.深入研究SALL4基因及蛋白的功能,將有助于闡明白血病的髮病機製,為治療白血病提供新靶點.
SALL4여조혈계통악성종류적발생유밀절관계.심입연구SALL4기인급단백적공능,장유조우천명백혈병적발병궤제,위치료백혈병제공신파점.
SALL4 gene is closely related to body malformations related diseases, embryonic stem cell development, and hematopoietic malignancies. SALL4 can activate hematopoietic stem cell through Wnt signaling pathways, and promote continued proliferation of leukemia stem cells, leading to leukemia. In-depth study of SALL4 gene and its protein function will help clarify the pathogenesis of leukemia, providing a new target for the treatment of leukemia.
