国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2009年
4期
284-287
,共4页
利钠肽 脑%脑梗死%预后
利鈉肽 腦%腦梗死%預後
리납태 뇌%뇌경사%예후
natriuretic peptide,brain%cerebral infarction%prognosis
目的 探讨脑钠肽(brain natriuretic peptide,BNP)对急性脑梗死患者的预后价值.方法 纳入65例首发急性脑梗死患者和32名正常对照者.病例组神经功能缺损采用中国卒中量表(Chinese Stroke Scale,CSS)评价.血浆BNP浓度采用荧光免疫定量法检测.病例组死亡和复发性卒中事件进行随访.比较事件组与非事件组血浆BNP浓度,分析血浆BNP浓度与预后不良的关系.结果 急性腩梗死患者血浆BNP浓度为(238.7±131.6)pg/ml,显著高于健康对照组的(38.7±23.8)pg/ml(P<0.01).随访期间有9例(13.8%)患者死亡,8例(12.3%)复发非致死性卒中.死亡/复发性卒中事件组患者基线血浆BNP浓度为(304.0±134.9)pg/ml,显著高于非事件组的(214.4±120.9)pg/ml(P<0.01).血浆NBP浓度与CSS评分之间存在显著相火性(r=-0.359,P<0.05).对各种危险凶素进行多变量分析表明,BNP水平(OR=3.5,95%CI 2.1～5.8;P<0.01)、高龄(OR=4.1,95%CI 1.7～9.2;P<0.01)和CSS评分(OR=2.6,95%CI 1.6-4.3;P<0.01)均为转归不良的独立预测因素.结论 血浆BNP水平升高是急性脑梗死患者近期死亡和复发的独立预测因素.
目的 探討腦鈉肽(brain natriuretic peptide,BNP)對急性腦梗死患者的預後價值.方法 納入65例首髮急性腦梗死患者和32名正常對照者.病例組神經功能缺損採用中國卒中量錶(Chinese Stroke Scale,CSS)評價.血漿BNP濃度採用熒光免疫定量法檢測.病例組死亡和複髮性卒中事件進行隨訪.比較事件組與非事件組血漿BNP濃度,分析血漿BNP濃度與預後不良的關繫.結果 急性腩梗死患者血漿BNP濃度為(238.7±131.6)pg/ml,顯著高于健康對照組的(38.7±23.8)pg/ml(P<0.01).隨訪期間有9例(13.8%)患者死亡,8例(12.3%)複髮非緻死性卒中.死亡/複髮性卒中事件組患者基線血漿BNP濃度為(304.0±134.9)pg/ml,顯著高于非事件組的(214.4±120.9)pg/ml(P<0.01).血漿NBP濃度與CSS評分之間存在顯著相火性(r=-0.359,P<0.05).對各種危險兇素進行多變量分析錶明,BNP水平(OR=3.5,95%CI 2.1～5.8;P<0.01)、高齡(OR=4.1,95%CI 1.7～9.2;P<0.01)和CSS評分(OR=2.6,95%CI 1.6-4.3;P<0.01)均為轉歸不良的獨立預測因素.結論 血漿BNP水平升高是急性腦梗死患者近期死亡和複髮的獨立預測因素.
목적 탐토뇌납태(brain natriuretic peptide,BNP)대급성뇌경사환자적예후개치.방법 납입65례수발급성뇌경사환자화32명정상대조자.병례조신경공능결손채용중국졸중량표(Chinese Stroke Scale,CSS)평개.혈장BNP농도채용형광면역정량법검측.병례조사망화복발성졸중사건진행수방.비교사건조여비사건조혈장BNP농도,분석혈장BNP농도여예후불량적관계.결과 급성남경사환자혈장BNP농도위(238.7±131.6)pg/ml,현저고우건강대조조적(38.7±23.8)pg/ml(P<0.01).수방기간유9례(13.8%)환자사망,8례(12.3%)복발비치사성졸중.사망/복발성졸중사건조환자기선혈장BNP농도위(304.0±134.9)pg/ml,현저고우비사건조적(214.4±120.9)pg/ml(P<0.01).혈장NBP농도여CSS평분지간존재현저상화성(r=-0.359,P<0.05).대각충위험흉소진행다변량분석표명,BNP수평(OR=3.5,95%CI 2.1～5.8;P<0.01)、고령(OR=4.1,95%CI 1.7～9.2;P<0.01)화CSS평분(OR=2.6,95%CI 1.6-4.3;P<0.01)균위전귀불량적독립예측인소.결론 혈장BNP수평승고시급성뇌경사환자근기사망화복발적독립예측인소.
Objective To investigate the prognostic value of plasma brain natriuretic peptide (BNP) in patients with acute cerebral infarction. Methods Sixty-five patients with first-ever acute cerebral infarction and 32 healthy controls were recruited. The neurological deficits in patients with cerebral infarction were evaluated by using Chinese Stroke Scale (CSS).Plasma BNP levels were detected by immunofluorescence technique. Death and recurrent stroke events were followed up. Plasma BNP levels were compared between an event group and a non-event group, and the relationship between plasma BNP levels and poor prognosis was analyzed.Results Plasma BNP levels in patients with acute cerebral infarction was significantly higher than those in healthy controls (238.7 ± 131.6 pg/ml vs 38.7±23.8 pg/ml, P <0.01). Nine patients (13.8%) died, and 8 (12.3%) had nonfatal recurrent stroke during the follow-up period. Compared to the non-event group, the baseline plasma BNP levels in the death/recurrent stroke event group were significantly higher (304.0 ± 134.9 pg/ml vs 214.4 ± 120.9 pg/ml,P < 0.01). There was significant correlation between plasma BNP levels and CSS scores (r = -0.359, P <0.05). After performing multivariate analysis of various risk factors, it found that BNP levels (OR = 3.5, 95 % CI 2.1 to 5.8, P < 0.01), advanced age (OR = 4.1,95% CI 1.7 to 9.2, P <0.01) and CSS scores (OR =2.6, 95% CI 1.6 to 4.3, P <0.01)were the independent predictors of poor outcome. Conclusions The increased BNP levels are the recent death and recurrent independent predictors in patients with acute cerebral infarction.
