中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2010年
6期
414-417
,共4页
黄育文%张念华%童冬梅%冯璇%张美辨%何继亮
黃育文%張唸華%童鼕梅%馮璇%張美辨%何繼亮
황육문%장념화%동동매%풍선%장미변%하계량
药物调剂%氟尿嘧啶%抗肿瘤药%职业暴露
藥物調劑%氟尿嘧啶%抗腫瘤藥%職業暴露
약물조제%불뇨밀정%항종류약%직업폭로
Drug compounding%Fluorouracil%Antineoplastic agents%Occupational exposure
目的 评价医院静脉药物配置中心(PIV AS)作业环境中5-氟尿嘧啶(5-Fu)的污染情况,发现抗癌药物的污染环节.方法 采集不同区域表面、物品的样品,经洗脱后,用紫外-可见光分光光度法测定5-Fu浓度.结果 空气样品中未检出5-Fu.生物安全柜内操作台表面、左侧、右侧、内侧和前窗表面5-Fu浓度分别为(22.00±6.35)、(13.99±2.46)、(14.13±0.72)、(7.25±1.19)、(9.87±1.23) ng/cm2,明显高于非使用区域的相应位置[分别为(3.14±0.04)、(5.43±0.65)、(2.26±0.17)、(2.26±0.17)、(3.63±0.46) ng/cm2,差异均有统计学意义(P<0.05).操作台下方地板、距安全柜正面1 m处地板、准备间地板、阳台地板、更衣室垃圾桶旁边地板上5-Fu浓度分别为(18.19±5.22)、(10.25±2.57)、(11.64±2.53)、(99.89±14.06)、(24.54±0.23)ng/cm2,明显高于非使用区域地板上的5-Fu浓度[(3.36±0.11)ng/cm2],差异均有统计学意义(P<0.05或P<0.01).配置间桌面、准备间桌面5-Fu浓度[分别为(7.22±1.04)、(11.81±1.18)ng/cm]明显高于非使用区域[(5.56±0.14)ng/cm2],差异均有统计学意义(P<0.05或P<0.01).物流进窗口、出窗口和配置间门内把手擦拭物5-Fu浓度明显高于非使用区域相应表面,差异有统计学意义(P<0.05或P<0.01),而配置间门边地板、配置间门外把手与非使用区域相应表面相比,差异无统计学意义(P>0.05).药袋、药筐表面5-Fu浓度与相应表面对照比较,差异有统计学意义(P<0.05).配置人员外层口罩、内层口罩与相应对照比较,差异无统计学意义(P>0.05).配置人员双手外层和左手内层手套、核对人员手套的5-Fu浓度明显高于相应对照,差异有统计学意义(P<0.05或P<0.01).结论 抗癌药物配置、核对和医疗垃圾处理是抗癌药物污染的重要环节.
目的 評價醫院靜脈藥物配置中心(PIV AS)作業環境中5-氟尿嘧啶(5-Fu)的汙染情況,髮現抗癌藥物的汙染環節.方法 採集不同區域錶麵、物品的樣品,經洗脫後,用紫外-可見光分光光度法測定5-Fu濃度.結果 空氣樣品中未檢齣5-Fu.生物安全櫃內操作檯錶麵、左側、右側、內側和前窗錶麵5-Fu濃度分彆為(22.00±6.35)、(13.99±2.46)、(14.13±0.72)、(7.25±1.19)、(9.87±1.23) ng/cm2,明顯高于非使用區域的相應位置[分彆為(3.14±0.04)、(5.43±0.65)、(2.26±0.17)、(2.26±0.17)、(3.63±0.46) ng/cm2,差異均有統計學意義(P<0.05).操作檯下方地闆、距安全櫃正麵1 m處地闆、準備間地闆、暘檯地闆、更衣室垃圾桶徬邊地闆上5-Fu濃度分彆為(18.19±5.22)、(10.25±2.57)、(11.64±2.53)、(99.89±14.06)、(24.54±0.23)ng/cm2,明顯高于非使用區域地闆上的5-Fu濃度[(3.36±0.11)ng/cm2],差異均有統計學意義(P<0.05或P<0.01).配置間桌麵、準備間桌麵5-Fu濃度[分彆為(7.22±1.04)、(11.81±1.18)ng/cm]明顯高于非使用區域[(5.56±0.14)ng/cm2],差異均有統計學意義(P<0.05或P<0.01).物流進窗口、齣窗口和配置間門內把手抆拭物5-Fu濃度明顯高于非使用區域相應錶麵,差異有統計學意義(P<0.05或P<0.01),而配置間門邊地闆、配置間門外把手與非使用區域相應錶麵相比,差異無統計學意義(P>0.05).藥袋、藥筐錶麵5-Fu濃度與相應錶麵對照比較,差異有統計學意義(P<0.05).配置人員外層口罩、內層口罩與相應對照比較,差異無統計學意義(P>0.05).配置人員雙手外層和左手內層手套、覈對人員手套的5-Fu濃度明顯高于相應對照,差異有統計學意義(P<0.05或P<0.01).結論 抗癌藥物配置、覈對和醫療垃圾處理是抗癌藥物汙染的重要環節.
목적 평개의원정맥약물배치중심(PIV AS)작업배경중5-불뇨밀정(5-Fu)적오염정황,발현항암약물적오염배절.방법 채집불동구역표면、물품적양품,경세탈후,용자외-가견광분광광도법측정5-Fu농도.결과 공기양품중미검출5-Fu.생물안전거내조작태표면、좌측、우측、내측화전창표면5-Fu농도분별위(22.00±6.35)、(13.99±2.46)、(14.13±0.72)、(7.25±1.19)、(9.87±1.23) ng/cm2,명현고우비사용구역적상응위치[분별위(3.14±0.04)、(5.43±0.65)、(2.26±0.17)、(2.26±0.17)、(3.63±0.46) ng/cm2,차이균유통계학의의(P<0.05).조작태하방지판、거안전거정면1 m처지판、준비간지판、양태지판、경의실랄급통방변지판상5-Fu농도분별위(18.19±5.22)、(10.25±2.57)、(11.64±2.53)、(99.89±14.06)、(24.54±0.23)ng/cm2,명현고우비사용구역지판상적5-Fu농도[(3.36±0.11)ng/cm2],차이균유통계학의의(P<0.05혹P<0.01).배치간탁면、준비간탁면5-Fu농도[분별위(7.22±1.04)、(11.81±1.18)ng/cm]명현고우비사용구역[(5.56±0.14)ng/cm2],차이균유통계학의의(P<0.05혹P<0.01).물류진창구、출창구화배치간문내파수찰식물5-Fu농도명현고우비사용구역상응표면,차이유통계학의의(P<0.05혹P<0.01),이배치간문변지판、배치간문외파수여비사용구역상응표면상비,차이무통계학의의(P>0.05).약대、약광표면5-Fu농도여상응표면대조비교,차이유통계학의의(P<0.05).배치인원외층구조、내층구조여상응대조비교,차이무통계학의의(P>0.05).배치인원쌍수외층화좌수내층수투、핵대인원수투적5-Fu농도명현고우상응대조,차이유통계학의의(P<0.05혹P<0.01).결론 항암약물배치、핵대화의료랄급처리시항암약물오염적중요배절.
Objective To investigate the level of occupational exposure to 5-fluorouracil (5-Fu) in the pharmacy intravenous admixture service (PIVAS) of a hospital, and identify the sources of 5-Fu contami-nation. Methods The 5-Fu concentrations in air, on the surface of different areas in PIVAS and personal pro-tective equipments were detected using UV-vis spectrophotometry. Results The 5-Fu in air could not be de-tected. The 5-Fu concentrations on five different surfaces of biological safety cabinets were (22.00±6.35), (13.99±2.46), (14.13±0.72), (7.25±1.19) and (9.87±1.23) ng/cm2, respectively, which were significantly higher than those [(3.14±0.04),(5.43±0.65),(2.26±0.17),(2.26±0.17) and (3.63±0.46) ng/cm2] of corre-sponding controls (P<0.05orP<0.01).The5-Fu concentrations of the floor under cabinets [(18.19±5.22) ng/cm2], the floor in front of cabinets [(10.25±2.57)ng/cm2], the office floor [(11.64±2.53) ng/cm2], the terrace floor [(99.89±14.06 )ng/cm2], the floor beside trash can in dressing room [(24.54±0.23) ng/cm2] were significantly higher than those of control [ (3.36±0.11) ng/cm2] (P<0.05 or P<0.01). The 5-Fu concentrations of the tables in preparation room [(7.22±1.04)ng/cm2] and the tables in office [(11.81±1.18) ng/cm2] were significantly higher than those of control [(5.56±0.14) ng/cm2] (P<0.05 or P<0.01). The 5-Fu concentrations of the indoor handle in preparation room were significantly higher than those of controls (P<0.05 or P<0.01). 5-Fu concen-trations on the surfaces of outdoor handle and floor beside door in preparation room were not significantly in-creased compared with controls (P>0.05). The 5-Fu concentrations on the surfaces of infusion bags, transfer box, transfer trays were significantly higher than those of controls (P<0.05). The differences of 5-Fu concentrations between outer and inner masks and controls were not significant (P>0.05). The 5-Fu concentrations of gloves of preparing and checking staffs were significantly higher than those of controls (P<0.05 or P<0.01). Conclusion The preparing and checking process of 5-Fu and the treatment of medical wastes are major sources of 5-Fu contamination.
