国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2012年
5期
399-401
,共3页
肿瘤%增殖性%骨髓%BCR/ABL%JAK2V617F
腫瘤%增殖性%骨髓%BCR/ABL%JAK2V617F
종류%증식성%골수%BCR/ABL%JAK2V617F
neoplasm%proliferative%marrow%BCR/ABL%JAK2V617F
目的 加强对骨髓增殖性肿瘤(MPN)的认识,提高其诊疗水平.方法 选择2007年3月至2012年2月江苏省兴化市人民医院收治的53例MPN患者为研究对象.回顾性分析其临床资料和相关实验室检查结果.结果 ①MPN发病高峰年龄为40～79岁,占86.79％(46/53);以慢性粒细胞白血病(CML)最为多见,占66.04％(35/53);临床表现不典型,脾大占77.36％.②MPN中不同疾病外周血血红蛋白(HB),RBC,WBC及PLT差异有统计学意义(P＜0.05).③6例真性红细胞增多症(PV)和4例原发性血小板增多症(ET)患者进行了JAK2V617F突变基因检查,阳性率分别为83.33％和75％;9例CML-慢性期患者检测了BCR/ABL基因,阳性率为100％.结论 MPN有发病年轻化的趋势,脾大为常见体征,血细胞持续增多结合JAK2V617F突变基因和BCR/ABL基因检测,可以准确诊断MPN,避免漏诊误诊.
目的 加彊對骨髓增殖性腫瘤(MPN)的認識,提高其診療水平.方法 選擇2007年3月至2012年2月江囌省興化市人民醫院收治的53例MPN患者為研究對象.迴顧性分析其臨床資料和相關實驗室檢查結果.結果 ①MPN髮病高峰年齡為40～79歲,佔86.79％(46/53);以慢性粒細胞白血病(CML)最為多見,佔66.04％(35/53);臨床錶現不典型,脾大佔77.36％.②MPN中不同疾病外週血血紅蛋白(HB),RBC,WBC及PLT差異有統計學意義(P＜0.05).③6例真性紅細胞增多癥(PV)和4例原髮性血小闆增多癥(ET)患者進行瞭JAK2V617F突變基因檢查,暘性率分彆為83.33％和75％;9例CML-慢性期患者檢測瞭BCR/ABL基因,暘性率為100％.結論 MPN有髮病年輕化的趨勢,脾大為常見體徵,血細胞持續增多結閤JAK2V617F突變基因和BCR/ABL基因檢測,可以準確診斷MPN,避免漏診誤診.
목적 가강대골수증식성종류(MPN)적인식,제고기진료수평.방법 선택2007년3월지2012년2월강소성흥화시인민의원수치적53례MPN환자위연구대상.회고성분석기림상자료화상관실험실검사결과.결과 ①MPN발병고봉년령위40～79세,점86.79％(46/53);이만성립세포백혈병(CML)최위다견,점66.04％(35/53);림상표현불전형,비대점77.36％.②MPN중불동질병외주혈혈홍단백(HB),RBC,WBC급PLT차이유통계학의의(P＜0.05).③6례진성홍세포증다증(PV)화4례원발성혈소판증다증(ET)환자진행료JAK2V617F돌변기인검사,양성솔분별위83.33％화75％;9례CML-만성기환자검측료BCR/ABL기인,양성솔위100％.결론 MPN유발병년경화적추세,비대위상견체정,혈세포지속증다결합JAK2V617F돌변기인화BCR/ABL기인검측,가이준학진단MPN,피면루진오진.
Objective To enhance the awareness of myeloproliferative neoplasms(MPN)and improve the diagnosis and treatment of the diseases.Methods From May 2007 to February 2012,a total of 53 cases of MPN patients who were treated by Xinghua People's Hospital were included in this study. A retrospective analysis of these patients' clinical data and laboratory test results were carried out.Results ① The peak age of MPN onset was 40 to 79 years old,accounting for 86.79％ (46/53). Chronic myeloid leukemia(CML) was the most common of these patients,accounting for 66.04％ (35/53).Splenomegaly was a typical clinical manifestations for MPN patients and there were 41 splenomegaly patients in all of the cases,accounting for77.36％. () There were significant differences in peripheral blood cells among the MPN patients(P＜0.05).JAK2V617F gene mutation was detected in 6 cases of polycythemia vera (PV) and 4 cases of essential thrombocythemia (ET) patients were detected the JAK2V617F mutation,with the positive rates of 83.33％ and 75％,respectively.BCR/ABL mutation was detected in all of 9 CML-chronic phase patients.Conclusions Incidence of MPN was the trend of younger.Enlarged spleen was a common sign.It would be an effective means to make accurate diagnosis and avoid misdiagnosis of MPN for combining the continue increasing blood cells and gene mutation of JAK2V617F and BCR/ABL.
