国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2012年
1期
45-47
,共3页
光%细胞衰老%面部皮肤病
光%細胞衰老%麵部皮膚病
광%세포쇠로%면부피부병
Light%Cell aging%Facial dermatoses
光线性弹性组织变性的形成机制包括弹性纤维变性和堆积.弹性纤维的变性涉及活性氧簇增多、成纤维细胞的损伤和衰老、弹性蛋白酶和基质金属蛋白酶生成增加.堆积机制主要包括成纤维细胞合成弹性纤维增多、弹性蛋白分别与溶菌酶和皮肤来源的抗白细胞蛋白酶结合抵抗弹性蛋白酶降解、组织蛋白酶K活性降低等.组织蛋白酶K在光线性弹性组织变性堆积中的作用机制可能是未来研究光老化的新方向.
光線性彈性組織變性的形成機製包括彈性纖維變性和堆積.彈性纖維的變性涉及活性氧簇增多、成纖維細胞的損傷和衰老、彈性蛋白酶和基質金屬蛋白酶生成增加.堆積機製主要包括成纖維細胞閤成彈性纖維增多、彈性蛋白分彆與溶菌酶和皮膚來源的抗白細胞蛋白酶結閤牴抗彈性蛋白酶降解、組織蛋白酶K活性降低等.組織蛋白酶K在光線性彈性組織變性堆積中的作用機製可能是未來研究光老化的新方嚮.
광선성탄성조직변성적형성궤제포괄탄성섬유변성화퇴적.탄성섬유적변성섭급활성양족증다、성섬유세포적손상화쇠로、탄성단백매화기질금속단백매생성증가.퇴적궤제주요포괄성섬유세포합성탄성섬유증다、탄성단백분별여용균매화피부래원적항백세포단백매결합저항탄성단백매강해、조직단백매K활성강저등.조직단백매K재광선성탄성조직변성퇴적중적작용궤제가능시미래연구광노화적신방향.
The pathogenesis of solar elastosis consists of the degeneration and accumulation of elastic fibers.The degeneration of elastic fibers is related to increased reactive oxygen species,damage and aging of dermal fibroblasts and elevated production of elastase and matrix metalloproteinases.The accumulation of elastotic material is mainly associated with raised synthesis of elastic fibers,counteraction of elastic fibers combined with lysozymes and skin-derived antileukoprotease against elastase degradation,decreased activity of cathepsin K,etc.In the future,the action mechanism of cathepsin K in solar elastosis and elastotic material degradation may become a new focus in photoaging research.