CAJ | 학술논문

Th17细胞是一种新近发现的不同于Th1、Th2细胞的CD4+效应性T细胞亚群,其分化受到局部微环境中不同细胞因子的调节,如TGF-β、IL-6促进初始CD4+T细胞分化为Th17细胞,而IL-27等则是抑制Th17分化的重要因子.Th17细胞以分泌IL-17、IL-21、IL-22等致炎细胞因子为主要特征,在对抗机体内多种细菌、真菌、病毒感染中发挥着重要作用,但同时也可能通过炎症反应而引起病理性损伤.因此,平衡Th17细胞在微生物感染中的保护效应与损伤作用才能有效地保护机体.
Th17세포시일충신근발현적불동우Th1、Th2세포적CD4+효응성T세포아군,기분화수도국부미배경중불동세포인자적조절,여TGF-β、IL-6촉진초시CD4+T세포분화위Th17세포,이IL-27등칙시억제Th17분화적중요인자.Th17세포이분비IL-17、IL-21、IL-22등치염세포인자위주요특정,재대항궤체내다충세균、진균、병독감염중발휘착중요작용,단동시야가능통과염증반응이인기병이성손상.인차,평형Th17세포재미생물감염중적보호효응여손상작용재능유효지보호궤체.
Recent studies have defined a new subset of CD4+ effector T cells-the T helper 17 (Th17)lineage which is distinct from Th1 and Th2 lineages. Various cytokines in microenvironment regulate the differentiation of Th17 cells. TGF-β and IL-6 are responsible for the differentiation of naive T cells into Th17 cells.IL-27 negatively regulates the development of Th17 cells. Th17 cells that produce proinflammatory cytokines including Il-17, IL-21 and IL-22 have been shown to play an important role in defene against bacterial, fungal and viral infections and participating pathologic consequences. Accordingly, a balance between controlling infections and limiting immunopathogenesis of Th17 cells needs to be achieved.