中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
6期
530-532
,共3页
不对称二甲基精氨酸%脑小血管病%脑白质损伤%认知功能障碍
不對稱二甲基精氨痠%腦小血管病%腦白質損傷%認知功能障礙
불대칭이갑기정안산%뇌소혈관병%뇌백질손상%인지공능장애
Asymmetric dimethylarginine%Cerebral small vessel disease%White matter lesions%Cognitive function
目的 研究血浆不对称二甲基精氨酸水平与脑小血管病患者脑白质损伤程度及认知功能水平之间的关系.方法 随机选取小血管病变所致脑白质损伤患者120例,根据蒙特利尔认知评价(Montred cognitive assessment,MoCA)量表将患者分为认知功能障碍组及非认知功能障碍组；采用高效液相色谱法测定所有患者血浆中不对称二甲基精氨酸水平,并通过Scheltens半定量评定表评价脑白质损伤程度.比较2组患者血浆不对称二甲基精氨酸水平及脑白质损伤程度之间的差异,并通过相关分析评价血浆不对称二甲基精氨酸水平与脑白质损伤程度及认知功能障碍之间的关系.结果 认知功能障碍组患者42例,非认知功能障碍组患者78例；认知功能障碍组患者血浆不对称二甲基精氨酸水平[(1.57±0.56) μg/ml]及脑白质损伤程度评分[(8.01±2.50)分]均明显高于非认知功能障碍组患者[(0.89±0.23) μg/ml,(2.49±0.59)分],差异均有统计学意义(P＜0.01).相关分析结果表明认知功能障碍组患者血浆不对称二甲基精氨酸水平与脑白质损伤程度及认知功能水平均呈正相关,相关系数分别为0.913与0.837(均P＜0.01).结论 不对称二甲基精氨酸可能参与了小血管病变患者脑白质的损伤过程,通过检测血浆不对称二甲基精氨酸水平可能有助于脑小血管病相关认知功能障碍的预防与早期诊断.
目的 研究血漿不對稱二甲基精氨痠水平與腦小血管病患者腦白質損傷程度及認知功能水平之間的關繫.方法 隨機選取小血管病變所緻腦白質損傷患者120例,根據矇特利爾認知評價(Montred cognitive assessment,MoCA)量錶將患者分為認知功能障礙組及非認知功能障礙組；採用高效液相色譜法測定所有患者血漿中不對稱二甲基精氨痠水平,併通過Scheltens半定量評定錶評價腦白質損傷程度.比較2組患者血漿不對稱二甲基精氨痠水平及腦白質損傷程度之間的差異,併通過相關分析評價血漿不對稱二甲基精氨痠水平與腦白質損傷程度及認知功能障礙之間的關繫.結果 認知功能障礙組患者42例,非認知功能障礙組患者78例；認知功能障礙組患者血漿不對稱二甲基精氨痠水平[(1.57±0.56) μg/ml]及腦白質損傷程度評分[(8.01±2.50)分]均明顯高于非認知功能障礙組患者[(0.89±0.23) μg/ml,(2.49±0.59)分],差異均有統計學意義(P＜0.01).相關分析結果錶明認知功能障礙組患者血漿不對稱二甲基精氨痠水平與腦白質損傷程度及認知功能水平均呈正相關,相關繫數分彆為0.913與0.837(均P＜0.01).結論 不對稱二甲基精氨痠可能參與瞭小血管病變患者腦白質的損傷過程,通過檢測血漿不對稱二甲基精氨痠水平可能有助于腦小血管病相關認知功能障礙的預防與早期診斷.
목적 연구혈장불대칭이갑기정안산수평여뇌소혈관병환자뇌백질손상정도급인지공능수평지간적관계.방법 수궤선취소혈관병변소치뇌백질손상환자120례,근거몽특리이인지평개(Montred cognitive assessment,MoCA)량표장환자분위인지공능장애조급비인지공능장애조；채용고효액상색보법측정소유환자혈장중불대칭이갑기정안산수평,병통과Scheltens반정량평정표평개뇌백질손상정도.비교2조환자혈장불대칭이갑기정안산수평급뇌백질손상정도지간적차이,병통과상관분석평개혈장불대칭이갑기정안산수평여뇌백질손상정도급인지공능장애지간적관계.결과 인지공능장애조환자42례,비인지공능장애조환자78례；인지공능장애조환자혈장불대칭이갑기정안산수평[(1.57±0.56) μg/ml]급뇌백질손상정도평분[(8.01±2.50)분]균명현고우비인지공능장애조환자[(0.89±0.23) μg/ml,(2.49±0.59)분],차이균유통계학의의(P＜0.01).상관분석결과표명인지공능장애조환자혈장불대칭이갑기정안산수평여뇌백질손상정도급인지공능수평균정정상관,상관계수분별위0.913여0.837(균P＜0.01).결론 불대칭이갑기정안산가능삼여료소혈관병변환자뇌백질적손상과정,통과검측혈장불대칭이갑기정안산수평가능유조우뇌소혈관병상관인지공능장애적예방여조기진단.
Objective To study the relationship between the plasma level of asymmetric dimethylarginine (ADMA) and the damage degree of white matter and the changes of cognitive function in patients with cerebral small vessel disease.Methods 120 patients with white matter lesions,induced by cerebral small vessel disease,were randomly selected.All patients were divided into group with or without cognitive dysfunction according to the results of MoCA scale.The plasma level of ADMA was detected with high-perfomance liquid chromatography method.Scheltens semi-quantitative evaluation was used to detect the damage degree of white matter.Correlation analysis was used to evaluate the relationship between the plasma level of ADMA and white matter lesions and cognitive dysfunction.Results There were 42 patients with cognitive dysfunction and 78 patients without cognitive dysfunction.The plasma level of ADMA in patients with cognitive dysfunction ( ( 1.57 ±0.56) μg/ml) was significantly higher than patients without cognitive dysfunction ( (0.89 ±0.23 ) μg/ml) (P ＜ 0.01 ).Scheltens semi-quantitative evaluationfor patients with cognitive dysfunction and patients without cognitive dysfunction was 8.01 ± 2.50and 2.49 ± 0.59,respectively.There was significant difference between this two groups (P ＜ 0.01 ).The plasma level of ADMA positively correlated with the damage degree of white matter lesions and the changes of cognitive function.The correlation coefficients were 0.913 and 0.837,respectively ( All P ＜ 0.01 ).Conclusion ADMA may be involved in the process of white matter damage caused by cerebral small vessel disease.The detection for plasma levels of ADMA may contribute to the prevention and early diagnosis of patients with cognitive dysfunction caused by cerebral small vessel disease.
