中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
4期
30-32
,共3页
占葆娥%吕琪%张春雷%王晓忠%黄涛%冯玉丽
佔葆娥%呂琪%張春雷%王曉忠%黃濤%馮玉麗
점보아%려기%장춘뢰%왕효충%황도%풍옥려
前S1抗原%乙肝标志物%酶联免疫吸附法
前S1抗原%乙肝標誌物%酶聯免疫吸附法
전S1항원%을간표지물%매련면역흡부법
Pre-S1%HBV marker%ELISA
目的 探讨HBV血清标志物与乙肝病毒前S1抗原(Pre-S1Ag)检测结果的关系.方法 应用酶联免疫吸附试验法(ELISA)检测610患者的常规乙肝病毒血清标志物和乙肝病毒前S1抗原.结果 本组HBsAg(+)、HBeAg(+)、抗-HBcAg(+)血清样本226份,Pre-S1Ag阳性检出率为85.84%;HBsAg(+)、HBeAg(+)血清样本45份,Pre-S1Ag阳性检出率为93.33%;HBsAg(+)、抗-HBeAg(+)、抗-HBcAg(+)血清样本298份,Pre-S1Ag阳性检出率为44.97%;HBsAg(+)、抗-HBcAg(+)血清样本41份,Pre-S1Ag阳性检出率为70.73%.HBeAg(+)组Pre-S1Ag检出率为87.08%,HBeAg(-)组PreS1 Ag检出率为35.80%,两者比较差异均具有统计学意义(P＜0.05).抗-HBeAg(+)组Pre-S1Ag检出率为64.50%,抗-HBcAg(-)组Pre-S1Ag检出率为82.55%,两者比较差异均具有统计学意义(P＜0.05).结论 Pre-S1Ag是HBV复制的可靠指标,与乙肝标志物联合检测可相互补充.
目的 探討HBV血清標誌物與乙肝病毒前S1抗原(Pre-S1Ag)檢測結果的關繫.方法 應用酶聯免疫吸附試驗法(ELISA)檢測610患者的常規乙肝病毒血清標誌物和乙肝病毒前S1抗原.結果 本組HBsAg(+)、HBeAg(+)、抗-HBcAg(+)血清樣本226份,Pre-S1Ag暘性檢齣率為85.84%;HBsAg(+)、HBeAg(+)血清樣本45份,Pre-S1Ag暘性檢齣率為93.33%;HBsAg(+)、抗-HBeAg(+)、抗-HBcAg(+)血清樣本298份,Pre-S1Ag暘性檢齣率為44.97%;HBsAg(+)、抗-HBcAg(+)血清樣本41份,Pre-S1Ag暘性檢齣率為70.73%.HBeAg(+)組Pre-S1Ag檢齣率為87.08%,HBeAg(-)組PreS1 Ag檢齣率為35.80%,兩者比較差異均具有統計學意義(P＜0.05).抗-HBeAg(+)組Pre-S1Ag檢齣率為64.50%,抗-HBcAg(-)組Pre-S1Ag檢齣率為82.55%,兩者比較差異均具有統計學意義(P＜0.05).結論 Pre-S1Ag是HBV複製的可靠指標,與乙肝標誌物聯閤檢測可相互補充.
목적 탐토HBV혈청표지물여을간병독전S1항원(Pre-S1Ag)검측결과적관계.방법 응용매련면역흡부시험법(ELISA)검측610환자적상규을간병독혈청표지물화을간병독전S1항원.결과 본조HBsAg(+)、HBeAg(+)、항-HBcAg(+)혈청양본226빈,Pre-S1Ag양성검출솔위85.84%;HBsAg(+)、HBeAg(+)혈청양본45빈,Pre-S1Ag양성검출솔위93.33%;HBsAg(+)、항-HBeAg(+)、항-HBcAg(+)혈청양본298빈,Pre-S1Ag양성검출솔위44.97%;HBsAg(+)、항-HBcAg(+)혈청양본41빈,Pre-S1Ag양성검출솔위70.73%.HBeAg(+)조Pre-S1Ag검출솔위87.08%,HBeAg(-)조PreS1 Ag검출솔위35.80%,량자비교차이균구유통계학의의(P＜0.05).항-HBeAg(+)조Pre-S1Ag검출솔위64.50%,항-HBcAg(-)조Pre-S1Ag검출솔위82.55%,량자비교차이균구유통계학의의(P＜0.05).결론 Pre-S1Ag시HBV복제적가고지표,여을간표지물연합검측가상호보충.
Objective To discuss relationship of hepatitis B virus gerum markers and Pre-S1 antigen.Methods Analyze the markers of HBV in blood serum and pre-S1 of HBV in 610 patients with ELISA.Results Pre-S1 antigen positive detection rate was 85.84% in 226 blood serum samples of HBsAg(+),HBeAg(+) and anti-HBcAg(+),Pre-S1 antigen positive detection rate was 93.33% in 45 blood serum samples of HBsAg(+) and anti-HBeAg(+).Pre-S1 antigen positive detection rate was 44.97% in 298 blood serum samples of HBsAg (+),anti-HBeAg(+) and anti-HBcAg(+).Pre-S1 antigen positive detection rate was 70.73% in 41 blood serum samples of HBsAg(+) and anti-HBcAg(+).The detection rate of Pre-S1 Ag was 87.08% in HBeAg(+) group and 35.80% in HBeAg(-) group,and there was significant difference between two groups(P＜0.05).The detection rate of Pre-S1Ag was 64.50% in anti-HBcAg(+) group and 82.55% in anti-HBcAg(-) group,and there was significant difference between two groups(P＜0.05).Conclusion Pre-S1Ag is a credible index of HBV replication,and may be helpful for HBV markers in detecting.
