中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2003年
29期
3968-3969
,共2页
新生血管化,病理性%血管生成因子%垂体肿瘤
新生血管化,病理性%血管生成因子%垂體腫瘤
신생혈관화,병이성%혈관생성인자%수체종류
目的:蛋白在垂体腺瘤中表达,探讨抗白细胞分化抗原(Cluster of differ-entiation)CD34单抗标记的微血管密度(Mi-crovascular Density,MVD)与垂体腺瘤分级的关系及其临床意义,对患者选择更有效和安全有利于患者社会生活的治疗手段提供理论依据.方法:采用免疫组化SP法对1998-05/2001-07 4l例垂体腺瘤组织及5例正常垂体组织中CD34的表达进行检测.结果:41例垂体腺瘤组织中平均MVD为20.9±8.0,5例正常垂体组织的平均MVD为12.2±2.4,二者差异具有显著性意义(t=2.4.P＜0.05).其中平均MVD(个/高倍视野)值在23例侵蚀型垂体腺瘤组(Ⅲ～V级)为27.0±4.8,在18例封闭型垂体组织(Ⅰ～Ⅱ级)为13.2±2.6,侵蚀型垂体腺瘤组的平均MVD与封闭型垂体腺瘤组和正常垂体组织组之间的差异均有显著性(t=10.9,P＜0.01).而封闭型垂体腺瘤组和正常垂体组织组平均MVD的之间差异无显著性意义(P＞0.05).结论:抗CD34单抗标记的肿瘤微血管密度与垂体腺瘤的临床分级密切相关,可反映垂体腺瘤侵袭性行为的使用指标,以指导临床医生选择更为切实、安全及对患者生理、心理、精神和主观感受都有益处的治疗方案.
目的:蛋白在垂體腺瘤中錶達,探討抗白細胞分化抗原(Cluster of differ-entiation)CD34單抗標記的微血管密度(Mi-crovascular Density,MVD)與垂體腺瘤分級的關繫及其臨床意義,對患者選擇更有效和安全有利于患者社會生活的治療手段提供理論依據.方法:採用免疫組化SP法對1998-05/2001-07 4l例垂體腺瘤組織及5例正常垂體組織中CD34的錶達進行檢測.結果:41例垂體腺瘤組織中平均MVD為20.9±8.0,5例正常垂體組織的平均MVD為12.2±2.4,二者差異具有顯著性意義(t=2.4.P＜0.05).其中平均MVD(箇/高倍視野)值在23例侵蝕型垂體腺瘤組(Ⅲ～V級)為27.0±4.8,在18例封閉型垂體組織(Ⅰ～Ⅱ級)為13.2±2.6,侵蝕型垂體腺瘤組的平均MVD與封閉型垂體腺瘤組和正常垂體組織組之間的差異均有顯著性(t=10.9,P＜0.01).而封閉型垂體腺瘤組和正常垂體組織組平均MVD的之間差異無顯著性意義(P＞0.05).結論:抗CD34單抗標記的腫瘤微血管密度與垂體腺瘤的臨床分級密切相關,可反映垂體腺瘤侵襲性行為的使用指標,以指導臨床醫生選擇更為切實、安全及對患者生理、心理、精神和主觀感受都有益處的治療方案.
목적:단백재수체선류중표체,탐토항백세포분화항원(Cluster of differ-entiation)CD34단항표기적미혈관밀도(Mi-crovascular Density,MVD)여수체선류분급적관계급기림상의의,대환자선택경유효화안전유리우환자사회생활적치료수단제공이론의거.방법:채용면역조화SP법대1998-05/2001-07 4l례수체선류조직급5례정상수체조직중CD34적표체진행검측.결과:41례수체선류조직중평균MVD위20.9±8.0,5례정상수체조직적평균MVD위12.2±2.4,이자차이구유현저성의의(t=2.4.P＜0.05).기중평균MVD(개/고배시야)치재23례침식형수체선류조(Ⅲ～V급)위27.0±4.8,재18례봉폐형수체조직(Ⅰ～Ⅱ급)위13.2±2.6,침식형수체선류조적평균MVD여봉폐형수체선류조화정상수체조직조지간적차이균유현저성(t=10.9,P＜0.01).이봉폐형수체선류조화정상수체조직조평균MVD적지간차이무현저성의의(P＞0.05).결론:항CD34단항표기적종류미혈관밀도여수체선류적림상분급밀절상관,가반영수체선류침습성행위적사용지표,이지도림상의생선택경위절실、안전급대환자생리、심리、정신화주관감수도유익처적치료방안.
AIM: To investigate the expressions of cluster of differentiation(CD) 34 in pituitary adenoma tissues and explore the relationship between microvascular density(MVD) and clinicobiological behavior in human pituitary adenoma.METHODS: The expression of CD34 in 41 cases of human pituitary ade-noma and 5 cases of normal pituitary tissues were investigated with immunohistochemistry.RESULTS: The MVD were 20. 9 ± 8. 0 and 12.2 ± 2.4 in the pituitary adenoma tissues and normal pituitary tissues, respectively, and there were significant differences between them( t =2.4, P ＜ 0. 05). The MVD in the 23 cases of invasive type(grade Ⅲ - Ⅴ) and 18 cases of enclosed type(grade Ⅰ- Ⅱ) of pituitary adenoma were 27.0 ±4. 8 and 13.2 ±2.6, respectively. There were significant differences between invasive type and enclosed type and normal pituitary tissues as well( t = 10.9, ＜0.01), but there was no significant difference between enclosed type and normal pituitary( P ＞ 0.05).There are intimate correlation between CD34 marked MVD and clinical type of pituitary adenoma, MVD may be the important marker for the biological invasive behaviors in pituitary adenoma.
