CAJ | 학술논문

目的:制备一种用于关节炎的夜间治疗的具有漂浮和脉冲释药特性的盐酸青藤碱时辰治疗给药系统,进行体外释药研究.方法:以盐酸青藤碱为模型药物采用压制包衣法制得包芯漂浮脉冲片;通过体外释药试验,考察影响脉冲片药物释放的因素;并结合溶蚀和吸水试验对脉冲片的释药机理进行探讨.结果:在体外释放时,盐酸青藤碱漂浮型脉冲释放片漂浮性能良好,经一定时滞后药物呈脉冲释放.随片芯膨胀程度增加和体外释放搅拌转速增加,释药时滞缩短.结论:盐酸青藤碱漂浮型脉冲片具有良好的漂浮性能,经一定时滞后呈脉冲释药.
목적:제비일충용우관절염적야간치료적구유표부화맥충석약특성적염산청등감시신치료급약계통,진행체외석약연구.방법:이염산청등감위모형약물채용압제포의법제득포심표부맥충편;통과체외석약시험,고찰영향맥충편약물석방적인소;병결합용식화흡수시험대맥충편적석약궤리진행탐토.결과:재체외석방시,염산청등감표부형맥충석방편표부성능량호,경일정시체후약물정맥충석방.수편심팽창정도증가화체외석방교반전속증가,석약시체축단.결론:염산청등감표부형맥충편구유량호적표부성능,경일정시체후정맥충석약.
AIM : To prepare a phase-specific drug delivery system with floating and pulsatile release of sinome-nine hydrochloride and evaluate in vitro drug release behavior. METHODS: The floating and pulsatile-release of coat-core tablets were prepared by press-coated technics. The effects of factors influencing release characteristic of the drug were investigated by dissolution test, and to elucidate the mechanism of drug release of the tablets with erosion and water-uptake test. RESULTS: The tablets had typical floating and pulsatile release properties with a lag time rapid release. The lag-time was shortened with the increase of expansion ratio of tablet core and rotation speed of stirrer. The lag-time was prolonged with the increase of pH and ionic strength of dissolution media.CONCLUSION: The tablet could float and rapidly release drug at the predetermined time.