国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2012年
2期
105-107
,共3页
原癌基因%细胞凋亡%肿瘤
原癌基因%細胞凋亡%腫瘤
원암기인%세포조망%종류
Proto-oncogenes%Apoptosis%Neoplasms
Pim-3作为表达丝氨酸和(或)苏氨酸激酶活性的原癌基因pim家族新成员,与pim-1、pim-2在序列、结构和功能上高度相似,通过磷酸化众多特异性底物而在细胞周期改变、细胞凋亡以及某些肿瘤发生中起重要调控作用.
Pim-3作為錶達絲氨痠和(或)囌氨痠激酶活性的原癌基因pim傢族新成員,與pim-1、pim-2在序列、結構和功能上高度相似,通過燐痠化衆多特異性底物而在細胞週期改變、細胞凋亡以及某些腫瘤髮生中起重要調控作用.
Pim-3작위표체사안산화(혹)소안산격매활성적원암기인pim가족신성원,여pim-1、pim-2재서렬、결구화공능상고도상사,통과린산화음다특이성저물이재세포주기개변、세포조망이급모사종류발생중기중요조공작용.
Pim-3,a new member of the the proto-oncogene pim family which expresses serine and threonine kinase activity,shows a high similar to pim-1 and pim-2 at the function,structure and sequence.Pim-3 plays an important regulative role in the cell cycle transform,cell apoptosis and occurrence of the malignant tumors by phosphorylating numerous specific substrates.
