CAJ | 학술논문

目的探讨血浆氨基末端脑钠肽前体(NT-proBNP)对冠心病合并代谢综合征患者远期心血管事件的预测意义.方法经冠状动脉造影证实的165例冠心病合并代谢综合征患者,在入院时测定NT-pro 水平,通过2年随访,观察其对远期心血管事件的预测意义.结果冠心病合并代谢综合征患者NT-proBNP水平显著高于合并稳定型心绞痛组(P＜0.01).2年后共发生心血管事件45例,调整了高血压、糖尿病、吸烟、高敏C反应蛋白等传统危险因素后,Cox风险回归提示NT-proBNP＞ 111.58 ng/L是预测远期心血管事件的独立危险之一(相对危险度2.67,P＜0.01).结论 NT-proBNP是冠心病合并代谢综合征患者发生远期心血管事件的独立危险因素之一.
목적 탐토혈장안기말단뇌납태전체(NT-proBNP)대관심병합병대사종합정환자원기심혈관사건적예측의의.방법 경관상동맥조영증실적165례관심병합병대사종합정환자,재입원시측정NT-pro 수평,통과2년수방,관찰기대원기심혈관사건적예측의의.결과 관심병합병대사종합정환자NT-proBNP수평현저고우합병은정형심교통조(P＜0.01).2년후공발생심혈관사건45례,조정료고혈압、당뇨병、흡연、고민C반응단백등전통위험인소후,Cox풍험회귀제시NT-proBNP＞ 111.58 ng/L시예측원기심혈관사건적독립위험지일(상대위험도2.67,P＜0.01).결론 NT-proBNP시관심병합병대사종합정환자발생원기심혈관사건적독립위험인소지일.
Objective To explore the prognostic value for cardiovascular events of elevated NT-proBNP in coronary heart disease(CHD) patients with metabolic syndrome(MS).Methods The level of NT-proBNP was measured in 165 CHD patients with MS diagnosed by coronary angiography.After 2 years follow-up,we recorded the corresponding cardiovascular events in those patients.Results The NT-proBNP level was much higher in ACS group than that in SCHD group( P ＜ 0.01 ).There were totally 45 events after 2 years.After adjustment of traditional risk factors including hypertension,diabetes,smoking history and high sensitivity C reactive protein( hs-CRP),Cox proportional hazard analysis indicated that high NT-proBNP level( ＞ 111.58ng/L)was an independent risk factor for future events (relative risk 2.67,P ＜0.01 ).Conclusion Elevated NT-proBNP level might be one of the independent risk factor for cardiovascular events in CHD patiens with MS.