CAJ | 학술논문

胚胎干细胞体外定向诱导分化的研究已成为发育生物学和细胞移植治疗学的研究热点,但伦理及免疫排斥问题一直阻碍胚胎干细胞(ES)的研究和临床应用.近两年,科学家成功地从多种成体细胞获得了诱导性多能干细胞(iPs细胞),iPS细胞具有和胚胎千细胞相似的特性,由于其可来自自体成体细胞,因而可避开伦理及免疫排斥问题,是胚胎十细胞良好的替代材料,具有广阔的应用前景.iPS只有诱导分化为成熟的功能细胞才能用于疾病的治疗.主要介绍iPS细胞向成熟细胞分化的研究现状及目前存在的一些问题.
배태간세포체외정향유도분화적연구이성위발육생물학화세포이식치료학적연구열점,단윤리급면역배척문제일직조애배태간세포(ES)적연구화림상응용.근량년,과학가성공지종다충성체세포획득료유도성다능간세포(iPs세포),iPS세포구유화배태천세포상사적특성,유우기가래자자체성체세포,인이가피개윤리급면역배척문제,시배태십세포량호적체대재료,구유엄활적응용전경.iPS지유유도분화위성숙적공능세포재능용우질병적치료.주요개소iPS세포향성숙세포분화적연구현상급목전존재적일사문제.
Research on the in vitro differentiation of embryonic stem cell(ES) is one of the hotspots in the study about developmental biology and cell transplantation therapy. But ethical issues and immune rejection remained to be the reasons which obstruct the progress. Recently, scientists have successfully obtained a kind of phripotent stem cell named induced phripotent stem cells (iPS). Since iPS posses similar properties with ES and can be autologously derived from patients themselves, it is a potential substitute of ES beth in the basic research and clinical application and the above mentioned problems can be avoided. However, iPS must differentiate to specific cells before being used in the clinical therapeutic research. The present article provides a concise summary of current progress on the differentiation ofiPS cell as well as some existing problems.