CAJ | 학술논문

探讨CIM~+CD28~-T细胞在Graves眼病(GO)中的免疫致病作用.采用流式细胞仪分析GO、Graves病无GO患者和健康对照者CIM~+CIY28~-T细胞γ-干扰素(IFN-γ)、白细胞介素2(IL-2)和IL-4的表达.结果显示,GO组CIM~+CD28~-T细胞比例显著增高(P<0.05),胞内高表达IFN-γ(P<0.05)、低表达IL-2(P<0.05),与GO临床活动度评分(CAS)密切相关(P<0.05).IL-4表达在3组间无明显差异.结果提示高分泌IFN-γ的CIM~+CD28~-T细胞与GO病理损害有关.
탐토CIM~+CD28~-T세포재Graves안병(GO)중적면역치병작용.채용류식세포의분석GO、Graves병무GO환자화건강대조자CIM~+CIY28~-T세포γ-간우소(IFN-γ)、백세포개소2(IL-2)화IL-4적표체.결과 현시,GO조CIM~+CD28~-T세포비례현저증고(P<0.05),포내고표체IFN-γ(P<0.05)、저표체IL-2(P<0.05),여GO림상활동도평분(CAS)밀절상관(P<0.05).IL-4표체재3조간무명현차이.결과 제시고분비IFN-γ적CIM~+CD28~-T세포여GO병리손해유관.
The immune effect of CD4~+CD28~-T cells on Graves'ophthalmopathy(GO)was investigated.The expressions of interferon-γ(IFN-γ),interleukin-2(IL-2),and IL-4 in CD4~+ CD28~-T ceils were assayed by flow cytometry in GO patients,Graves'disease(GD)patients without ophthalmopathy,and healthy control subjects.The results showed that the percentage of CD4~+CD28~-T cells significantly increased in GO patients(P<0.05),with increased IFN-γ expression(P<0.05)and decreased IL-2 expression(P<0.05).These changes were closely correlated with clinical activity score(P<0.05).There were no significant differences in IL-4 expression among three groups.The resuh suggests that CIM~+ CD28~- T cells which hishly secrete IFN-γare related to the pathological lesion of GO.s w