CAJ | 학술논문

目的探讨胰头癌根治术后长期生存的影响因素.方法回顾性分析我院1996年1月至2004年1月58例胰头癌根治术患者的临床资料,并以SPSS10.0统计软件包行COX多元回归分析.结果 58例胰头痛根治性切除术患者中,男30例,女28例,均为胰腺导管癌.行标准胰十二指肠切除术14例,扩大根治术44例.全组1、3、5年生存率为46.6%(27/58)、29.3%(17/58)和8.6%(5/58).扩大根治术组1、3、5年生存率分别为43.2%(19/44)、22.7%(10/44)和6.8%(3/44).COX多元回归分析表明UICC分期、胰周神经浸润和围术期输血对预后有显著影响.结论胰头癌根治性切除术后长期生存率仍不理想,应重视早期诊断和综合治疗措施.
목적 탐토이두암근치술후장기생존적영향인소.방법 회고성분석아원1996년1월지2004년1월58례이두암근치술환자적림상자료,병이SPSS10.0통계연건포행COX다원회귀분석.결과 58례이두통근치성절제술환자중,남30례,녀28례,균위이선도관암.행표준이십이지장절제술14례,확대근치술44례.전조1、3、5년생존솔위46.6%(27/58)、29.3%(17/58)화8.6%(5/58).확대근치술조1、3、5년생존솔분별위43.2%(19/44)、22.7%(10/44)화6.8%(3/44).COX다원회귀분석표명UICC분기、이주신경침윤화위술기수혈대예후유현저영향.결론 이두암근치성절제술후장기생존솔잉불이상,응중시조기진단화종합치료조시.
Objective To analyze the clinical factors predicting long-term survival after curative resection of pancreatic head carcinoma. Methods The clinical data of 58 patients with ductal adenocarcinoma of pancreatic head who underwent curative resection of carcinoma of pancreatic head from 1996 to 2004 were collected and were analyzed by SPSS 10.0 with Cox Proportional Hazards Model. Results 58 patients, including 30 male and 28 female patients, were involved in this study. Pancreaticoduodenectomy were performed in 14 cases and extended resections were performed in 44 cases. The overall 1, 3, 5 year survival rates was 46.6%, 29.3% and 8.6%, respeclively. The 1,3, 5 year survival rates of pancreatoduodenectomy with extended regional lymphadenectomy was 43.1%, 22.7% and 6.8%, respectively. UICC staging, peri-pancreatic nerve invasion and blood infusion had significant effects on the prognosis after curative resection. Conclusions The long-term prognosis after curative resection of pancreatoduodenectomy was still dismal. Much importance should be paid to early diagnosis and comprehensive management for pancreatic head cancer.