CAJ | 학술논문

目的应用异体脱细胞真皮基质(ADM)移植修复口腔扁平苔藓(OLP)切除术后的创面,观察手术方法治疗OLP的临床效果.方法病变局限于口腔黏膜的OLP患者19例,手术切除病变组织,黏膜缺损区即刻移植ADM,随访时间20～36个月,平均30个月.结果 19例患者中,2例失访;9例痊愈,未见病损复发;5例好转,部分区域OLP病损复发,但复发病损出现在术区外侧缘;3例无效,移植区内病损复发.有效率为73.7%.结论手术切除OLP病变组织后移植ADM是治疗OLP的新途径,OLP的发病可能与口腔黏膜局部因素有关.
목적 응용이체탈세포진피기질(ADM)이식수복구강편평태선(OLP)절제술후적창면,관찰수술방법치료OLP적림상효과.방법 병변국한우구강점막적OLP환자19례,수술절제병변조직,점막결손구즉각이식ADM,수방시간20～36개월,평균30개월.결과 19례환자중,2례실방;9례전유,미견병손복발;5례호전,부분구역OLP병손복발,단복발병손출현재술구외측연;3례무효,이식구내병손복발.유효솔위73.7%.결론 수술절제OLP병변조직후이식ADM시치료OLP적신도경,OLP적발병가능여구강점막국부인소유관.
Objective To evaluate the clinical use and effect of acellular dermal matrix (ADM) in the repair of the defect of oral mucosa after operation of oral lichen planus ( OLP). Methods Ninety cases of OLP were treated surgically and the mucosa defect was repaired by ADM allograft immediately. All patients were followed up at mean 30 months (20-36 months) , and clinical examination was conducted to follow up the healing of the ADM graft. Results Two patients were lost follow-up. Nine were well repaired by ADM. Five patients were improved, and the new OLP was found outside the graft region. Three patients were failed, and the new OLP was found inside the graft region. The total success rate was 73. 7%. Conclusion Surgical repair of OLP cases with ADM allograft gave satisfactory results although being a relatively new method of treatment. The result indicated that the occurence of OLP may be come from the change of oral mucosa itself.