临床军医杂志
臨床軍醫雜誌
림상군의잡지
CLINICAL JOURNAL OF MEDICAL OFFICER
2001年
2期
32-34
,共3页
肾病%一氧化氮%氧化修饰低密度脂蛋白
腎病%一氧化氮%氧化脩飾低密度脂蛋白
신병%일양화담%양화수식저밀도지단백
目的 探讨NO及ox-LDL在肾病时的变化及其与肾功能的关系。方法 采用分光光度法和酶联免疫吸附法分别测定了48例各类肾病血中的NO和ox-LDL水平。结果 各类肾病患者血中NO和ox-LDL的水平均明显高于正常对照组(NO为(0.66±0.18)μmol/L,ox-LDL为(0.32±0.07)mg/L);NO随疾病的发展而逐渐降低，与病程长短成反比(r=-0.3019);ox-LDL则随疾病的进展而逐渐升高，与病程长短呈正相关(r=0.4102)，二者在肾病时呈明显负相关(r=-0.7186)。结论 肾病时机体过多地产生NO，也存在脂质过氧化程度增强，NO极有可能参与了肾病的发生、发展过程，ox-LDL则可能是肾病发生发展的始动因素，也是并发心脑血管疾病的危险因素。
目的 探討NO及ox-LDL在腎病時的變化及其與腎功能的關繫。方法 採用分光光度法和酶聯免疫吸附法分彆測定瞭48例各類腎病血中的NO和ox-LDL水平。結果 各類腎病患者血中NO和ox-LDL的水平均明顯高于正常對照組(NO為(0.66±0.18)μmol/L,ox-LDL為(0.32±0.07)mg/L);NO隨疾病的髮展而逐漸降低，與病程長短成反比(r=-0.3019);ox-LDL則隨疾病的進展而逐漸升高，與病程長短呈正相關(r=0.4102)，二者在腎病時呈明顯負相關(r=-0.7186)。結論 腎病時機體過多地產生NO，也存在脂質過氧化程度增彊，NO極有可能參與瞭腎病的髮生、髮展過程，ox-LDL則可能是腎病髮生髮展的始動因素，也是併髮心腦血管疾病的危險因素。
목적 탐토NO급ox-LDL재신병시적변화급기여신공능적관계。방법 채용분광광도법화매련면역흡부법분별측정료48례각류신병혈중적NO화ox-LDL수평。결과 각류신병환자혈중NO화ox-LDL적수평균명현고우정상대조조(NO위(0.66±0.18)μmol/L,ox-LDL위(0.32±0.07)mg/L);NO수질병적발전이축점강저，여병정장단성반비(r=-0.3019);ox-LDL칙수질병적진전이축점승고，여병정장단정정상관(r=0.4102)，이자재신병시정명현부상관(r=-0.7186)。결론 신병시궤체과다지산생NO，야존재지질과양화정도증강，NO겁유가능삼여료신병적발생、발전과정，ox-LDL칙가능시신병발생발전적시동인소，야시병발심뇌혈관질병적위험인소。
Objective To study the changes and relationships of nitric oxide (NO) and oxidatively modified low density lipoprotein (ox-LDL) in nephropathy. Method Spectrophotometry and exzyme linked immunosorbent assay (ELISA) were used to test the levels of NO and ox-LDL in serum or plasma of 49 patients with nephropathy. Result The NO and ox-LDL from 28 patients with primary glomerular, 21 with secondary glomerular were (1.34±0.25)μmol/L and (0.47±0.13)mg/L, (1.02±0.23)μmol/L and (0.69±0.18)mg/L respectively. The NO and ox-LDL levels were significantly higher than in controls ［(0.66±0.18)μmol/L and (0.32±0.07)mg/L］. The NO levels fell down with the progress of diseases (r=-0.301 9), while ox-LDL levels inceased (r=0.410 2), and the correlation coefficient between NO and ox-LDL was -0.718 6. Conclusion There was more NO in nephropathy which participated in the progress of nephropathy. The lipid peroxidation increased, and ox-LDL was not only the first factor in nephropathy, but the risky factor in cardivascular and cerebrovascular diseases.
