CAJ | 학술논문

肝脏具有很强的再生能力.肝损伤后,许多信号分子通过激活级联反应促进残肝细胞的转录因子AP1、NF-kB、STAT3等转录,进而促进G0期肝细胞进入G1期.然后,促进肝实质细胞和非实质细胞相继进行细胞周期,代偿丢失的肝脏细胞及恢复肝脏的生理功能.这一肝再生过程需要多条胞内信号通路调控,主要包括MAPK、JAK-STAT、NF-kB和RHO通路等.本文对近年这方面研究进展作一综述.
간장구유흔강적재생능력.간손상후,허다신호분자통과격활급련반응촉진잔간세포적전록인자AP1、NF-kB、STAT3등전록,진이촉진G0기간세포진입G1기.연후,촉진간실질세포화비실질세포상계진행세포주기,대상주실적간장세포급회복간장적생리공능.저일간재생과정수요다조포내신호통로조공,주요포괄MAPK、JAK-STAT、NF-kB화RHO통로등.본문대근년저방면연구진전작일종술.
The liver has very strong capacity to regenerate. After partial hepatectomy, signal molecules promote the remnant hepatocytes from G0phase to G1 through activating signaling cascade response to promote transcription of the transcription factors such as AP1, NF-kB, STAT3 etc. , then parenchymal and nonparen chymal cells enter the cell cycle sequentially to replenish the lost hepatocytes and to restore the hepatic physio logical functions. This course needs participation and regulation of multiple intracellular signaling pathways, mainly including MAPK, JAK-STAT, NF-kB and RHO signaling pathway etc. This article summarizes the recent progress of this aspect.