中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2010年
4期
406-408
,共3页
周永林%武鸣%赵金扣%王培桦%张庆兰%陈智高%梁萍%王辉%刘体亚%陆美琪%陈祖培
週永林%武鳴%趙金釦%王培樺%張慶蘭%陳智高%樑萍%王輝%劉體亞%陸美琪%陳祖培
주영림%무명%조금구%왕배화%장경란%진지고%량평%왕휘%류체아%륙미기%진조배
碘%甲状腺功能亢进症%患病率%流行病学
碘%甲狀腺功能亢進癥%患病率%流行病學
전%갑상선공능항진증%환병솔%류행병학
Iodine%Hyperthyroidism%Prevalence%Epidemiology
目的 通过对高碘与适碘乡人群甲状腺功能亢进症(甲亢)发病率的流行病学调查,分析高碘与甲亢的发生关系.方法 2006年,在江苏省选择饮用水含碘量较高的沛县孟庄乡(水碘中位数为1284.1μg/L)和饮用水含碘量适宜的邳州市新集乡(水碘中位数为77.9 μg/L),对两乡的所有人群进行甲状腺疾病筛查,对筛查出的可疑者进行检查及确诊,比较两乡甲亢患病率以及与人口学特征分布之间的差异.结果 高碘乡调查17471人,查出甲亢病人26人,患病率为1.49‰,其中男性患病率为0.75‰(7/9264),女性为2.32‰(19/8207);标化患病率为1.48‰.适碘乡调查12 765人,查出甲亢病人27人,患病率为2.12‰,其中男性患病率为0.96‰(7/6823),女性为3.26‰(20/5942);标化患病率为2.02‰.高碘乡甲亢患病率和标化患病率显著低于适碘乡(u值分别为2.88、2.89,P均<0.01).高碘乡女性患病率(2.32‰)低于适碘乡(3.37‰,u=4.03,P<0.01).高碘乡和适碘乡甲亢患病率均以20～50岁年龄组为高(19.36/万～38.96/万).高碘乡甲亢患者中Graves病占50.00%(13/26),显著高于适碘乡[29.41%(5/17),χ2=5.853,P<0.01].结论 长期慢性高碘摄入并没有增加甲亢发病危险,与适碘乡相比,高碘乡居民甲亢患病率反而下降,女性患病率高于男性.
目的 通過對高碘與適碘鄉人群甲狀腺功能亢進癥(甲亢)髮病率的流行病學調查,分析高碘與甲亢的髮生關繫.方法 2006年,在江囌省選擇飲用水含碘量較高的沛縣孟莊鄉(水碘中位數為1284.1μg/L)和飲用水含碘量適宜的邳州市新集鄉(水碘中位數為77.9 μg/L),對兩鄉的所有人群進行甲狀腺疾病篩查,對篩查齣的可疑者進行檢查及確診,比較兩鄉甲亢患病率以及與人口學特徵分佈之間的差異.結果 高碘鄉調查17471人,查齣甲亢病人26人,患病率為1.49‰,其中男性患病率為0.75‰(7/9264),女性為2.32‰(19/8207);標化患病率為1.48‰.適碘鄉調查12 765人,查齣甲亢病人27人,患病率為2.12‰,其中男性患病率為0.96‰(7/6823),女性為3.26‰(20/5942);標化患病率為2.02‰.高碘鄉甲亢患病率和標化患病率顯著低于適碘鄉(u值分彆為2.88、2.89,P均<0.01).高碘鄉女性患病率(2.32‰)低于適碘鄉(3.37‰,u=4.03,P<0.01).高碘鄉和適碘鄉甲亢患病率均以20～50歲年齡組為高(19.36/萬～38.96/萬).高碘鄉甲亢患者中Graves病佔50.00%(13/26),顯著高于適碘鄉[29.41%(5/17),χ2=5.853,P<0.01].結論 長期慢性高碘攝入併沒有增加甲亢髮病危險,與適碘鄉相比,高碘鄉居民甲亢患病率反而下降,女性患病率高于男性.
목적 통과대고전여괄전향인군갑상선공능항진증(갑항)발병솔적류행병학조사,분석고전여갑항적발생관계.방법 2006년,재강소성선택음용수함전량교고적패현맹장향(수전중위수위1284.1μg/L)화음용수함전량괄의적비주시신집향(수전중위수위77.9 μg/L),대량향적소유인군진행갑상선질병사사,대사사출적가의자진행검사급학진,비교량향갑항환병솔이급여인구학특정분포지간적차이.결과 고전향조사17471인,사출갑항병인26인,환병솔위1.49‰,기중남성환병솔위0.75‰(7/9264),녀성위2.32‰(19/8207);표화환병솔위1.48‰.괄전향조사12 765인,사출갑항병인27인,환병솔위2.12‰,기중남성환병솔위0.96‰(7/6823),녀성위3.26‰(20/5942);표화환병솔위2.02‰.고전향갑항환병솔화표화환병솔현저저우괄전향(u치분별위2.88、2.89,P균<0.01).고전향녀성환병솔(2.32‰)저우괄전향(3.37‰,u=4.03,P<0.01).고전향화괄전향갑항환병솔균이20～50세년령조위고(19.36/만～38.96/만).고전향갑항환자중Graves병점50.00%(13/26),현저고우괄전향[29.41%(5/17),χ2=5.853,P<0.01].결론 장기만성고전섭입병몰유증가갑항발병위험,여괄전향상비,고전향거민갑항환병솔반이하강,녀성환병솔고우남성.
Objective To examine the relationship between hyperthyroidism and excessive iodine intake from drinking water through epidemiological studies in the iodine excess and the iodine normal villages. Methods Mengzhuang village of Pei county and Xingji village of Pizhou city in Jiangsu province, with median water iodine concentration of 1284.1 μg/L and 77.9 μ/L, respectively,were selected in 2006. Thyroid diseases of all local residents in the two villages were assessed clinically to compare the prevalence and the distribution of hyperthyroidism. Results A total of 17 471 residents were recruited from the iodine excess village, 26 of them were diagnosed with hyperthyroidism. The prevalence of hyperthyroidism was 1.49‰, 0.75‰ (7/9264) in male,2.32‰( 19/8207) in female, and the age-standardized prevalence was 1.48‰. A total of 12 765 residents were recruited from the iodine normal village, among them 27 residents were diagnosed with hyperthyroidism. The prevalence of hyperthyroidism was 2.12‰, 0.96‰(7/6823) in male, 3.26‰(20/5942) in female, and the agestandardized prevalence was 2.02‰. The prevalence and age-standardized prevalence was significantly lower in the iodine excess village than those in the iodine normal village (u = 2.88, 2.89; all P < 0.01). The prevalence of hyperthyroidism was lower among females in the iodine excess village (2.32‰) than that in the iodine normal one (3.37‰, u = 2.89, P < 0.01). Residents aged 20 - 50 years had higher prevalence of hyperthyroidism[(19.36 -38.96 )/10 000]in the two villages. The proportion of Graves diseases was 50.00% (13/26) in the iodine excessvillage, higher than that in the iodine normal village[29.41%(5/17) , χ2 = 5.853, P < 0.01]. Conclusions Chronic excessive iodine intake does not increase the chance of suffering from hyperthyroidism. On the contrary, the prevalence of hyperthyroidism in the iodine excess village decreases significantly compared with that of the iodine normal village. The prevalence is higher among females.
