中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2011年
6期
625-628
,共4页
谷氨酰转肽酶%代谢综合征
穀氨酰轉肽酶%代謝綜閤徵
곡안선전태매%대사종합정
Serum gamma-glutamyltransferase%Metabolic syndrome
目的 探讨肝功能指标谷氨酰转肽酶(GGT)与代谢综合征(MS)组分体重指数(BMI)、血压、血脂及血糖之间的相关性.方法 选取天津市健康查体者4110名,按年龄分组(<65岁非老年组2058名,≥65岁老年组2052名),检测BMI、血压、空腹血糖(FPG)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、GGT、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血尿酸(UA);根据GGT水平分为正常组和异常组,以SPSS软件进行统计学分析.结果 MS患病率非老年组为14.6%(男200%,女4.6%),老年组为24.3%(男24.6%,女22.8%);MS与非MS组间比较,BMI、舒张压(DBP)、ALT、GGT、HDL-C、FPG、UA的差异有统计学意义(均P<0.05);GGT正常与异常组间比较,BMI、DBP、ALT、AST、TG、TC、HDL-C、LDL-C、UA、FPG差异均有统计学意义(均P<005);经Pearson相关性分析,GGT与BMI、DBP、TG、TC、FPG、UA呈正相关(r值分别为0.212、0.226、0.362、0.200、0.120、0.213,均P<0.01),与HDL-C负相关(r=-0 23,P<0.001);多因素回归分析提示校正性别、年龄、BMI因素后,DBP、TG、FPG、UA为GGT的危险因子(β值分别为0.170、0.293、0.107、0.094,均P<0 05).结论 GGT与MS各组分血压、血脂及血糖显著相关.
目的 探討肝功能指標穀氨酰轉肽酶(GGT)與代謝綜閤徵(MS)組分體重指數(BMI)、血壓、血脂及血糖之間的相關性.方法 選取天津市健康查體者4110名,按年齡分組(<65歲非老年組2058名,≥65歲老年組2052名),檢測BMI、血壓、空腹血糖(FPG)、穀丙轉氨酶(ALT)、穀草轉氨酶(AST)、GGT、甘油三酯(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、血尿痠(UA);根據GGT水平分為正常組和異常組,以SPSS軟件進行統計學分析.結果 MS患病率非老年組為14.6%(男200%,女4.6%),老年組為24.3%(男24.6%,女22.8%);MS與非MS組間比較,BMI、舒張壓(DBP)、ALT、GGT、HDL-C、FPG、UA的差異有統計學意義(均P<0.05);GGT正常與異常組間比較,BMI、DBP、ALT、AST、TG、TC、HDL-C、LDL-C、UA、FPG差異均有統計學意義(均P<005);經Pearson相關性分析,GGT與BMI、DBP、TG、TC、FPG、UA呈正相關(r值分彆為0.212、0.226、0.362、0.200、0.120、0.213,均P<0.01),與HDL-C負相關(r=-0 23,P<0.001);多因素迴歸分析提示校正性彆、年齡、BMI因素後,DBP、TG、FPG、UA為GGT的危險因子(β值分彆為0.170、0.293、0.107、0.094,均P<0 05).結論 GGT與MS各組分血壓、血脂及血糖顯著相關.
목적 탐토간공능지표곡안선전태매(GGT)여대사종합정(MS)조분체중지수(BMI)、혈압、혈지급혈당지간적상관성.방법 선취천진시건강사체자4110명,안년령분조(<65세비노년조2058명,≥65세노년조2052명),검측BMI、혈압、공복혈당(FPG)、곡병전안매(ALT)、곡초전안매(AST)、GGT、감유삼지(TG)、총담고순(TC)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、혈뇨산(UA);근거GGT수평분위정상조화이상조,이SPSS연건진행통계학분석.결과 MS환병솔비노년조위14.6%(남200%,녀4.6%),노년조위24.3%(남24.6%,녀22.8%);MS여비MS조간비교,BMI、서장압(DBP)、ALT、GGT、HDL-C、FPG、UA적차이유통계학의의(균P<0.05);GGT정상여이상조간비교,BMI、DBP、ALT、AST、TG、TC、HDL-C、LDL-C、UA、FPG차이균유통계학의의(균P<005);경Pearson상관성분석,GGT여BMI、DBP、TG、TC、FPG、UA정정상관(r치분별위0.212、0.226、0.362、0.200、0.120、0.213,균P<0.01),여HDL-C부상관(r=-0 23,P<0.001);다인소회귀분석제시교정성별、년령、BMI인소후,DBP、TG、FPG、UA위GGT적위험인자(β치분별위0.170、0.293、0.107、0.094,균P<0 05).결론 GGT여MS각조분혈압、혈지급혈당현저상관.
Objective To observe the relationship between serum gamma-glutamyltransferase (GGT) and the risk factors of metabolic syndrome (MS). Methods Between April and August 2010, a total of 4110 persons from the out-patient Department of Tianjin First CentralHospital, were divided into two groups, the less than and the older than 65-year-old groups. Items as body mass index (BMI), blood pressure, FPG, serum total cholesterol(TC) ,triglyceride(TG) ,alanine transaminase (ALT) , aspartate aminotransferase (AST) , GGT, serum high-density lipoprotein level (HDL-C) , serum low-density lipoprotein level (LDL-C) and uric acid(UA) were tested and data was analyzed by SPSS. All subjects were divided into normaland abnormal groups, according to the GGT level. Results 14.6 percent of thesubjects in the younger groups and 24.3 percent in the older groups were diagnosed as MS. Significant differences were noticed among MS groups and normal groups, regarding items as BMI, dystolic, ALT, GGT, HDL-C, FPG, and UA(F<0.05). There were significant differences between GGT normal group and abnormal group (F<0.05). The GGT levels were significant positively related to the levels of BMI, dystolic, TC, TG, FPG and UA with Rs as 0.212, 0.226, 0.362,0.200,0.120 and 0.213 (P<0.01), while negatively related to the HDL-C level (r=-0.23, P<0.001). Data from the regression analysis demonstrated thatdystolic, TG, FPG and UA were predictors for GGT (β =0.170, 0.293, 0.107, 0.094, P<0.05). Conclusion GGT levels were significantly related to the risk factors of metabolic syndrome.
