国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2009年
6期
442-445
,共4页
雌激素类%多态现,象遗传%乳腺肿瘤
雌激素類%多態現,象遺傳%乳腺腫瘤
자격소류%다태현,상유전%유선종류
Estrogens%Polymorphism,genetic%Breast neoplasms
雌激素是乳腺癌的主要危险因素,推测是通过雌激素受体影响乳腺癌的发病风险.因此,与雌激素合成和代谢相关的基因多态性被认为是乳腺癌的主要危险因子.与雌激素合成基因(CYP11A1、CYP17、CYP19)和代谢基因(CYP1A1、CYP1B1、CYP1A2)相关的基因多态性在调节乳腺癌易感性中具有一定意义.
雌激素是乳腺癌的主要危險因素,推測是通過雌激素受體影響乳腺癌的髮病風險.因此,與雌激素閤成和代謝相關的基因多態性被認為是乳腺癌的主要危險因子.與雌激素閤成基因(CYP11A1、CYP17、CYP19)和代謝基因(CYP1A1、CYP1B1、CYP1A2)相關的基因多態性在調節乳腺癌易感性中具有一定意義.
자격소시유선암적주요위험인소,추측시통과자격소수체영향유선암적발병풍험.인차,여자격소합성화대사상관적기인다태성피인위시유선암적주요위험인자.여자격소합성기인(CYP11A1、CYP17、CYP19)화대사기인(CYP1A1、CYP1B1、CYP1A2)상관적기인다태성재조절유선암역감성중구유일정의의.
Estrogens,the major risk factors for breast cancer,are speculated to affect breast cancer risk through estrogens receptor(ER), thus, genetic polymorphisms of the genes involved in the estrogens biosynthesis and metabolism are expected as the main risk factors for breast cancer. Polymorphisms of the genes involved in estrogens biosynthesis (CYP11A1, CYP17, CYP19) and metabolism (CYP1A1, CYP1B1, CYP1A2) in modulating the susceptibility of breast cancer is important.
