中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2011年
1期
24-26
,共3页
血管紧张素Ⅱ Ⅰ型受体拮抗剂%高血压%心律失常
血管緊張素Ⅱ Ⅰ型受體拮抗劑%高血壓%心律失常
혈관긴장소Ⅱ Ⅰ형수체길항제%고혈압%심률실상
AngiotensinⅡ type Ⅰ receptor blockers%Hypertension%Arrhythmia
目的 探讨氯沙坦对老年高血压患者室性心律失常的影响. 方法 65～89岁老年高血压合并室性心律失常患者78例随机分为氯沙坦治疗组及依那普利治疗组,疗程12个月.观察指标为血压、左室心肌质量指数及室性心律失常数. 结果治疗结束后两组的降压疗效相仿,差异无统计学意义(P＞0.05).左室心肌质量指数依那普利组[(109.2±15.4)g·m-2]低于氯沙坦组[(128.5±16.7)g·m-2](t=2.015,P＜0.05).室性心律失常数氯沙坦组[(628.5±176.8)次/24h]低于依那普利组[(852.9±215.7)次/24 h](t=2.417,P＜0.05).相关性分析结果显示,氯沙坦治疗组室性心律失常减少与血压下降(收缩压r=0.094,P＞0.05;舒张压r=0.08,P＞0.05)及左室心肌质量指数降低(r=0.104,P＞0.05)不相关. 结论尽管具有相似的降压疗效,但氯沙坦对老年高血压患者室性心律失常的疗效优于依那普利.
目的 探討氯沙坦對老年高血壓患者室性心律失常的影響. 方法 65～89歲老年高血壓閤併室性心律失常患者78例隨機分為氯沙坦治療組及依那普利治療組,療程12箇月.觀察指標為血壓、左室心肌質量指數及室性心律失常數. 結果治療結束後兩組的降壓療效相倣,差異無統計學意義(P＞0.05).左室心肌質量指數依那普利組[(109.2±15.4)g·m-2]低于氯沙坦組[(128.5±16.7)g·m-2](t=2.015,P＜0.05).室性心律失常數氯沙坦組[(628.5±176.8)次/24h]低于依那普利組[(852.9±215.7)次/24 h](t=2.417,P＜0.05).相關性分析結果顯示,氯沙坦治療組室性心律失常減少與血壓下降(收縮壓r=0.094,P＞0.05;舒張壓r=0.08,P＞0.05)及左室心肌質量指數降低(r=0.104,P＞0.05)不相關. 結論儘管具有相似的降壓療效,但氯沙坦對老年高血壓患者室性心律失常的療效優于依那普利.
목적 탐토록사탄대노년고혈압환자실성심률실상적영향. 방법 65～89세노년고혈압합병실성심률실상환자78례수궤분위록사탄치료조급의나보리치료조,료정12개월.관찰지표위혈압、좌실심기질량지수급실성심률실상수. 결과치료결속후량조적강압료효상방,차이무통계학의의(P＞0.05).좌실심기질량지수의나보리조[(109.2±15.4)g·m-2]저우록사탄조[(128.5±16.7)g·m-2](t=2.015,P＜0.05).실성심률실상수록사탄조[(628.5±176.8)차/24h]저우의나보리조[(852.9±215.7)차/24 h](t=2.417,P＜0.05).상관성분석결과현시,록사탄치료조실성심률실상감소여혈압하강(수축압r=0.094,P＞0.05;서장압r=0.08,P＞0.05)급좌실심기질량지수강저(r=0.104,P＞0.05)불상관. 결론진관구유상사적강압료효,단록사탄대노년고혈압환자실성심률실상적료효우우의나보리.
Objective To evaluate the effect of losartan on ventricular arrhythmia in elderly patients with hypertension.Methods The 78 hypertension subjects with ventricular arrhythmia aged 65 to 89 years were randomly assigned to treatment with losartan or placebo (enalapril) for 12 months. The blood pressure, left ventricular mass index and ventricular arrhythmia were observed and analyzed.Results After 12 months treatment, the pressure lowering effect was similar in losartan versus enalapril groups, there were no differences in systolic pressure decrement and diastolic pressure decrement between the two groups (P＞0. 05). Left ventricular mass index was lower in enalapril groupthaninlosartangroup [(109.2±15. 4) g · m-2 vs. (128.5±16. 7) g · m-2, t=2.015, P＜0. 05]. However, the prevalence of ventricular arrhythmia was lower in losartan group than in enalapril group [(628. 5±176.8)/24 h vs. (852.9±215.7)/24 h, t=2.417,P＜0.05]. No Pearson's correlations of reduction of ventricular arrhythmia with reduction of blood pressure (systolic: r=0. 094, P＞0. 05; diastolic: r= 0.08, P＞0. 05) and reduction of left ventricular mass index were found. in losartan group.Conclusions Initiation of antihypertensive treatment with losartan in elderly subjects appears to cause more reduction of ventricular arrhythmia than with enalapril, despite similar reduction of blood pressure.
