CAJ | 학술논문

目的了解尿路感染致病微生物谱及主要致病菌的耐药性,以指导临床合理用药.方法回顾性分析2005-2007年住院患者中段尿培养阳性的3117株致病微生物鉴定结果和主要致病菌耐药率.结果尿路感染致病微生物仍以细菌为主,其次为真菌、支原体和衣原体.大肠埃希菌仍占革兰阴性菌的首位,其中产超广谱β-内酰胺酶(ESBLs)阳性的比例高达51.2%,且耐药性明显高于ESBLs(-)菌株.主要革兰阳性球菌对万古霉素100%敏感,对呋喃妥因和氨苄西林相对敏感.结论尿路感染致病微生物仍以大肠埃希菌为主,但应关注真菌及支原体和衣原体感染的增加.临床上需根据药物敏感性试验结果慎重选择抗菌药物,并尽量避免联合使用抗菌药物.
목적 료해뇨로감염치병미생물보급주요치병균적내약성,이지도림상합리용약.방법 회고성분석2005-2007년주원환자중단뇨배양양성적3117주치병미생물감정결과화주요치병균내약솔.결과뇨로감염치병미생물잉이세균위주,기차위진균、지원체화의원체.대장애희균잉점혁란음성균적수위,기중산초엄보β-내선알매(ESBLs)양성적비례고체51.2%,차내약성명현고우ESBLs(-)균주.주요혁란양성구균대만고매소100%민감,대부남타인화안변서림상대민감.결론 뇨로감염치병미생물잉이대장애희균위주,단응관주진균급지원체화의원체감염적증가.림상상수근거약물민감성시험결과신중선택항균약물,병진량피면연합사용항균약물.
Objective To identify the spectrum of pathogenic microorganisms of urinary tract infection and the drug resistance in a hospital setting. Methods The pathogenic microorganisms isolated from 3117 mid-stream urine samples of patients admitted in Hangzhou First People's Hospital from 2005 to 2007 and their drug resistance results were retrospectively analyzed. Results Bacteria were the most prevalent microorganisms in the urinary tract infection, and followed by fungus, mycoplasma and chlamydia. Escherichia eoli accounted for the largest proportion of gram-negative bacteria, in which the ESBLs positive strains accounted for 51.2%, and their drug resistance rate was much higher than that of ESBLs negative strains. Main gram-positive coccobacteria was all sensitive to vancomycin, and relatively sensitive to nitrofurantnin and ampicillin. Conclusions Escherichia coli continue to prevail upon the spectrum of pathogenic microorganism of the urinary tract infection, and the fungus, mycoplasma and chlamydia infections are rising. Antibacterial agents should be used under the guidance of drug sensitivity test, and the combined use should be avoidd.