中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
1期
10-11
,共2页
氨氯地平%高血压%白蛋白尿
氨氯地平%高血壓%白蛋白尿
안록지평%고혈압%백단백뇨
Amlodipine%Hypertension%Proteinuria
目的 观察增大剂量的氨氯地平对高血压病患者血压及微量白蛋白尿的影响.方法 采用前瞻性、自身对照试验,为期12周.60例原发性高血压病伴微量白蛋白尿患者,氨氯地平起始剂量为2.Smg,每12小时1次,血压未达标者[坐位舒张压＞90 mm Hg(1 mm Hg=0.133 kPa)]每4周在原有基础上剂量增加1倍.治疗过程中监测血压及尿微量白蛋白及不良反应发生情况.结果 试验4、8、12周时血压均明显下降(P＜0.01).尿微量白蛋白4周时明显下降(P＜0.01),8周、12周与4周比较差异无统计学意义(P＞0.05).结论 氨氯地平的降压作用呈时间-剂量依赖性,小剂量氨氯地平已可发挥肾保护作用.
目的 觀察增大劑量的氨氯地平對高血壓病患者血壓及微量白蛋白尿的影響.方法 採用前瞻性、自身對照試驗,為期12週.60例原髮性高血壓病伴微量白蛋白尿患者,氨氯地平起始劑量為2.Smg,每12小時1次,血壓未達標者[坐位舒張壓＞90 mm Hg(1 mm Hg=0.133 kPa)]每4週在原有基礎上劑量增加1倍.治療過程中鑑測血壓及尿微量白蛋白及不良反應髮生情況.結果 試驗4、8、12週時血壓均明顯下降(P＜0.01).尿微量白蛋白4週時明顯下降(P＜0.01),8週、12週與4週比較差異無統計學意義(P＞0.05).結論 氨氯地平的降壓作用呈時間-劑量依賴性,小劑量氨氯地平已可髮揮腎保護作用.
목적 관찰증대제량적안록지평대고혈압병환자혈압급미량백단백뇨적영향.방법 채용전첨성、자신대조시험,위기12주.60례원발성고혈압병반미량백단백뇨환자,안록지평기시제량위2.Smg,매12소시1차,혈압미체표자[좌위서장압＞90 mm Hg(1 mm Hg=0.133 kPa)]매4주재원유기출상제량증가1배.치료과정중감측혈압급뇨미량백단백급불량반응발생정황.결과 시험4、8、12주시혈압균명현하강(P＜0.01).뇨미량백단백4주시명현하강(P＜0.01),8주、12주여4주비교차이무통계학의의(P＞0.05).결론 안록지평적강압작용정시간-제량의뢰성,소제량안록지평이가발휘신보호작용.
Objective To investigate the effect of increasing dose of amlodipine on blood pressure and microalbuminuria in patients with hypertension.Methods A prospective self- controlled clinical trail with 60 patients enrolled was performed in the 12 - week study of amlodipine.Dose of amlodipine was doubled every 4 weeks from the initial dose of 2.5 mg,q12 h for the inadequately controlled hypertension patients.Blood pressure and urinary protein excretion,side effects were recorded simultaneously.Results Blood pressure decreased remarkably after 4,8,12 weeks.Proteinuria decreased significantly after 4 weeks (P ＜ 0.01 ),there was no significant difference between 8th week,12th week and 4th week (P ＞ 0.05).Conclusions Amlodipine reduces blood pressure in a time - dose dependent manner.Small - dose amlodipine have protective effect on renal damage.
