CAJ | 학술논문

目的:对神经病理性疼痛患者进行抑郁评估,并检测外周血免疫球蛋白、补体及循环免疫复合物水平,外周血T细胞的表面标志物如CD3+、CD4+、CD8+等,比较伴抑郁状态的神经病理性疼痛患者体液免疫和细胞免疫的变化,观察抑郁状态对神经病理性疼痛患者的免疫是否有影响.方法:选择我院2006至2007年符合神经病理性疼痛纳入标准的疼痛门诊及住院患者,通过Zung'S抑郁自评量表了解病人抑郁情况;采集外周静脉血测定血常规、IgA、IgG、IgM、IgE、C3、C4、循环免疫复合物(CIC)、CD3+、CD4+、CD8+T细胞.结果:入选的86位神经病理情疼痛患者中一半以上(52名占60.47%)的患者合并有不同程度的抑郁状态,其中轻度抑郁的患者29名占总抑郁患者的55.77%.白细胞总数及淋巴细胞百分比和绝对值在有无抑郁情况的神经病理性疼痛患者中有显著差异(P<0.05),抑郁的患者较无抑郁的患者显著降低,但均在正常范围内.其他白细胞种类,IgG、IgA、IgM、IgE、C3、C4、CIC、CD3+、CD4+和CD8+等,在有无抑郁情况的神经病理情疼痛患者中没有显著差异(P>0.05).结论:神经病理性疼痛患者容易合并以轻度为主的不同程度的抑郁状态;神经病理性疼痛患者合并抑郁状态对免疫功能有轻微影响.
목적:대신경병이성동통환자진행억욱평고,병검측외주혈면역구단백、보체급순배면역복합물수평,외주혈T세포적표면표지물여CD3+、CD4+、CD8+등,비교반억욱상태적신경병이성동통환자체액면역화세포면역적변화,관찰억욱상태대신경병이성동통환자적면역시부유영향.방법:선택아원2006지2007년부합신경병이성동통납입표준적동통문진급주원환자,통과Zung'S억욱자평량표료해병인억욱정황;채집외주정맥혈측정혈상규、IgA、IgG、IgM、IgE、C3、C4、순배면역복합물(CIC)、CD3+、CD4+、CD8+T세포.결과:입선적86위신경병리정동통환자중일반이상(52명점60.47%)적환자합병유불동정도적억욱상태,기중경도억욱적환자29명점총억욱환자적55.77%.백세포총수급림파세포백분비화절대치재유무억욱정황적신경병이성동통환자중유현저차이(P<0.05),억욱적환자교무억욱적환자현저강저,단균재정상범위내.기타백세포충류,IgG、IgA、IgM、IgE、C3、C4、CIC、CD3+、CD4+화CD8+등,재유무억욱정황적신경병리정동통환자중몰유현저차이(P>0.05).결론:신경병이성동통환자용역합병이경도위주적불동정도적억욱상태;신경병이성동통환자합병억욱상태대면역공능유경미영향.
Objective:Observe the effect of depression on immunity of neuropathic pain patients.Methods:Patients clinically diagnosed at least by two pain physicians as neuropathie pain for more than 3 months,with the written consent to participale the clinical survey and to donate the blood for immune function test either in pain outpatient or pain ward in West China Hospital,from the year 2006 to 2007 were recruited.Zang's self-rating depression scales were used to assess extent of depression.Serum IgA、IgG、IgM,C3,C4 and circulating leukocyte,CD3、CD4,CD8 T cells were detected.Results:More than half of the patients accounted for 60.47 percent had various degrees of depression,among which,patients with mild depression were accounted for 55.77 percent of the total.Tne leukocyte number,lymphocyte percentage and absolute lymphocytes of the neurepathic pain patients with depression were significandy Iower than neuropathic pain patients with no depression(P<0.05),but were within normal range.Tne leukocyt number,neutrephil,lymphocytes,monocyte,IgM,C3,C4,CIC,CD3+,CD4+ and CD8+ were significantly lower in the patients with neuropathic pain(P<0.05).Other types of leukocytes,IgG,IgA,IgM,IgE,C3,C4,CIC,CD3+,CD4+ and CD8+ were had no significant difierence in neuropathic pain patients whether with depression or not(P>0.05).Conclusions:Neuropathie pain patlents tends to attack varying degrees of depression,expecially mild depression.Depression has mild effect on immunity of neuropathic pain patients.