中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2010年
1期
9-12
,共4页
牛京育%常蜀英%张均田%高和%何荆贵%何宇鸿%张宝和%吴智平%孟晓落%余华峰%王鲁宁
牛京育%常蜀英%張均田%高和%何荊貴%何宇鴻%張寶和%吳智平%孟曉落%餘華峰%王魯寧
우경육%상촉영%장균전%고화%하형귀%하우홍%장보화%오지평%맹효락%여화봉%왕로저
褪黑素%睡眠障碍%亚健康
褪黑素%睡眠障礙%亞健康
퇴흑소%수면장애%아건강
melatonin%sleep disorder%sub-health
目的 研究褪黑素(MT,改善睡眠药)对有睡眠障碍及患有非急性期心脑血管病的老年人睡眠状态的影响.方法 用多中心随机双盲和安慰剂平行对照试验设计,224例60岁以上亚健康和非急性期心脑血管病患者随机分为2组,试验组口服MT 3～6 mg;对照组口服安慰剂,均连服6个月.用匹兹堡睡眠质量指数(PSQI)进行评分.结果 服用MT 1-6月后,除第6项(催眠药物)外,PSQI总分均值显著下降,表明睡眠质量显著改善,较对照组均有显著改善.服用1月时,睡眠质量改善的有效率为69.3%;服用2,3,4,5,6月后,试验组睡眠质最指数总分持续稳步改善,有效率继续升高,显著优于对照组;6月时,达到睡眠质量改善的最佳效果,有效率为91.2%.结论 MT有显著改善老年人睡眠质量的生理作用.
目的 研究褪黑素(MT,改善睡眠藥)對有睡眠障礙及患有非急性期心腦血管病的老年人睡眠狀態的影響.方法 用多中心隨機雙盲和安慰劑平行對照試驗設計,224例60歲以上亞健康和非急性期心腦血管病患者隨機分為2組,試驗組口服MT 3～6 mg;對照組口服安慰劑,均連服6箇月.用匹玆堡睡眠質量指數(PSQI)進行評分.結果 服用MT 1-6月後,除第6項(催眠藥物)外,PSQI總分均值顯著下降,錶明睡眠質量顯著改善,較對照組均有顯著改善.服用1月時,睡眠質量改善的有效率為69.3%;服用2,3,4,5,6月後,試驗組睡眠質最指數總分持續穩步改善,有效率繼續升高,顯著優于對照組;6月時,達到睡眠質量改善的最佳效果,有效率為91.2%.結論 MT有顯著改善老年人睡眠質量的生理作用.
목적 연구퇴흑소(MT,개선수면약)대유수면장애급환유비급성기심뇌혈관병적노년인수면상태적영향.방법 용다중심수궤쌍맹화안위제평행대조시험설계,224례60세이상아건강화비급성기심뇌혈관병환자수궤분위2조,시험조구복MT 3～6 mg;대조조구복안위제,균련복6개월.용필자보수면질량지수(PSQI)진행평분.결과 복용MT 1-6월후,제제6항(최면약물)외,PSQI총분균치현저하강,표명수면질량현저개선,교대조조균유현저개선.복용1월시,수면질량개선적유효솔위69.3%;복용2,3,4,5,6월후,시험조수면질최지수총분지속은보개선,유효솔계속승고,현저우우대조조;6월시,체도수면질량개선적최가효과,유효솔위91.2%.결론 MT유현저개선노년인수면질량적생리작용.
Objective To study the influence of melatonin(MT)on the sleep of anxiety and depression in elderly with sleep disorder and elderly patients with non-acute cardiac and/or cerebral vascular diseases.Methods The effect of melatonin on sleep Was assessed in a multi-centers,randomized,double blinded and placebo paralleled comparison clinical study.Two hundreds twenty-four participants aged over 60 years old were cases in sub-health state or with non-acute cardiac and/or cerebral Vascular diseases.They were randomly seperated into two groups,and received ether MT(3-6 mg once daily)or starch for 6 months.AU of the subjects were assessed with Pittsburgh sleep quality index(PSQI).Results The participants'total score of PSQI decreased significantly after 1-6 months use of melatonin,representing the remarkable improvement in sleep quality.After the first month.69.3% showed improvement in sleep quality;through the second,third,fourth,five month,the improvement in total score had been going on,and was significantly better in melatonin group than the control group.At the end of the six month,the sleep quality showed the best improvement,with a 91.2% effective rate.Conclusion Melatonin has an remarkable physical effect of improving the sleep quality in old people.
