CAJ | 학술논문

目的探讨山莨菪碱对心肺复苏(CPR)后患者血清神经元特异性烯醇酶(NSE)、S100蛋白水平及神经功能的影响.方法 53例心搏骤停后经心肺复苏心搏恢复≥72h、需要进一步生命支持的患者,随机分为山莨菪碱组27例(山莨菪碱+常规综合治疗)和常规组26例(单纯常规综合治疗).分别于治疗后不同时间点检测血清NSE、S100蛋白水平,并以格拉斯哥昏迷评分(GCS)和神经功能缺损评分(NFI)判断临床疗效.结果与常规组比较,山莨菪碱组治疗后血清NSE、S100蛋白水平显著降低(P<0.05或P<0.01),GCS评分显著增高(P<0.05或P<0.01),NFI评分显著降低(P<0.05或P<0.01).结论山莨菪碱通过降低血清NSE、S100蛋白水平对心肺复苏后脑损伤起到一定保护作用.
목적 탐토산랑탕감대심폐복소(CPR)후환자혈청신경원특이성희순매(NSE)、S100단백수평급신경공능적영향.방법 53례심박취정후경심폐복소심박회복≥72h、수요진일보생명지지적환자,수궤분위산랑탕감조27례(산랑탕감+상규종합치료)화상규조26례(단순상규종합치료).분별우치료후불동시간점검측혈청NSE、S100단백수평,병이격랍사가혼미평분(GCS)화신경공능결손평분(NFI)판단림상료효.결과 여상규조비교,산랑탕감조치료후혈청NSE、S100단백수평현저강저(P<0.05혹P<0.01),GCS평분현저증고(P<0.05혹P<0.01),NFI평분현저강저(P<0.05혹P<0.01).결론 산랑탕감통과강저혈청NSE、S100단백수평대심폐복소후뇌손상기도일정보호작용.
Objective To observe the clinical effects of anisodamine on NSE,S100 protein and neurological functional status in the patients with successful cardiopulmonary resuscitation (CPR).Methods Fifty -three cases suffering from cardiac arrest recovered after CPR for more than 72hours, and were randomly divided into two groups: anisodamine group (n = 27) and conventional group (n = 26).The amount of NSE and S100 protein in serum were measured at different time after the treatment.The clinical curative effects were evaluated by Glasgow coma scale (GCS) and nerve functional insufficiency (NFI).Results Compared with conventional group, there were significant decreases in NSE ,S100 protein and NFI (P < 0.05 or P < 0.01), while GCS washigher in anisodamine group(P < 0.05 or P < 0.01).Conclusion Anisodamine can alleviate cerebral injury after cardiopulmonary resuscitation by decreasing the level of serum NSE and S100 protein.