CAJ | 학술논문

抗肿瘤药物相关肺毒性是引起呼吸衰竭的重要原因之一,其临床表现主要为肺部炎症表现、过敏性反应、血管渗透性反应及肺血管疾病等,发病机制与药物对肺部的直接毒性、机体的免疫反应以及毛细血管通透性增加等有关.因其表现无特异性,故诊断时应以排除法除外其他肺部疾病,一旦诊断明确,立即停用相关抗肿瘤药物并及时予大剂量激素冲击治疗.如何降低抗肿瘤药物的肺毒性将成为今后抗肿瘤药物研究的一个重点.
항종류약물상관폐독성시인기호흡쇠갈적중요원인지일,기림상표현주요위폐부염증표현、과민성반응、혈관삼투성반응급폐혈관질병등,발병궤제여약물대폐부적직접독성、궤체적면역반응이급모세혈관통투성증가등유관.인기표현무특이성,고진단시응이배제법제외기타폐부질병,일단진단명학,립즉정용상관항종류약물병급시여대제량격소충격치료.여하강저항종류약물적폐독성장성위금후항종류약물연구적일개중점.
Antineoplastic agents-induced pulmonary toxicity is one of important reasons causing respiratory failure,which clinical manifestations are pulmonary inflammation,allergic reaction,vascular permeability reaction and pulmonary vascular disease.All of these may be caused by drug toxicity,immune response and increased capillary permeability and so on.Because of the nonspecific performance,it is important to exclude the other lung diseases.Once the diagnosis is clear,the antineoplastic gents should be immediately stopped and the patients should be timely administered high-dose eorticosteroid therapy.How to reduce the pulmonary toxicity induced by antineoplastic agents is becoming one of the future focuses about antineoplastic agents research.