CAJ | 학술논문

近20年来,随着广谱抗生素、糖皮质激素、放疗、化疗的广泛应用,烧伤、器官移植、血液透析、肠外营养人数的增加以及艾滋病的流行等,侵袭性肺曲霉病的发病率日益增加.随着侵袭性肺曲霉病的发病机制以及早期诊断等相关研究不断深入,相关研究需建立在成功的动物模型基础上,所以动物模型的建立具有重要意义.本文对近几年肺曲霉病的动物模型研究作一综述.
근20년래,수착엄보항생소、당피질격소、방료、화료적엄범응용,소상、기관이식、혈액투석、장외영양인수적증가이급애자병적류행등,침습성폐곡매병적발병솔일익증가.수착침습성폐곡매병적발병궤제이급조기진단등상관연구불단심입,상관연구수건립재성공적동물모형기출상,소이동물모형적건립구유중요의의.본문대근궤년폐곡매병적동물모형연구작일종술.
In recent twenty years, with the extensive use of broad-spectrum antibiotics, corticosteroids, radiotherapy, chemotherapy, the increase of burns, organ transplantation, hemodialysis, parenteral nutrition, and the prevalence of acquired immune deficiency syndrome, the morbidity of invasive pulmonary aspergillosis is increasing. With the deep researches on mechanism and early diagnosis of invasive pulmonary aspergillosis, relevant research should be based on successful animal model, so the animal model is important. This article summaries the researches about animal model of pulmonary aspergillosis in recent years.