中华创伤骨科杂志
中華創傷骨科雜誌
중화창상골과잡지
CHINESE JOURNAL OF ORTHOPAEDIC TRAUMA
2011年
1期
21-24
,共4页
赵建宁%梅晓亮%郭亭%程秀红
趙建寧%梅曉亮%郭亭%程秀紅
조건저%매효량%곽정%정수홍
关节成形术,置换,髋%白细胞介素6%白细胞介素10%纤维蛋白原
關節成形術,置換,髖%白細胞介素6%白細胞介素10%纖維蛋白原
관절성형술,치환,관%백세포개소6%백세포개소10%섬유단백원
Arthroplasty,replacement,hip%Interleukin-6%Interleukin- 10%Fibrinogen
目的 探讨血清炎性因子白细胞介素(IL)-6、IL-10及纤维蛋白原(FBG)浓度在人工全髋关节置换术(THA)后的变化特点及意义.方法 选择初次行单侧THA的30例患者为观察组,其中男12例,女18例;年龄55～70岁(平均58.4岁),分别于术前1 d、术后1、3 d检测IL-6、IL-10及FBG浓度,并与对照组20例健康人群(男8例,女12例;年龄25～40岁,平均30.5岁)结果进行比较.结果 观察组患者THA后1 d血清中IL-6、IL-10及FBG浓度分别为(121.74±84.93)pg/mL、(14.92±11.80)pg/mL、(4833.2±314.3)mg/L,较对照组[(41.21±25.35)pg/mL、(8.14±7.25)pg/mL、(3097.2±771.3)mg/L]及术前1 d[(47.41±76.32)pg/mL、(8.30±10.69)pg/mL、(3497.2±677.2)mg/L]明显升高,差异均有统计学意义(P＜0.05＝.术后3 d血清中IL-6、IL-10及FBG浓度较术后1 d明显下降(P＜0.05＝,基本接近术前水平,与术前1 d比较差异均无统计学意义(P＞0.05).结论 炎症与血栓形成密切相关,THA后3 d是抗炎、抗凝治疗的关键.术后及时监测IL-6、IL-10及FBG浓度的变化,同时观察临床症状及生化指标,对于更好地掌握病情的变化及预防血栓形成具有一定临床意义.
目的 探討血清炎性因子白細胞介素(IL)-6、IL-10及纖維蛋白原(FBG)濃度在人工全髖關節置換術(THA)後的變化特點及意義.方法 選擇初次行單側THA的30例患者為觀察組,其中男12例,女18例;年齡55～70歲(平均58.4歲),分彆于術前1 d、術後1、3 d檢測IL-6、IL-10及FBG濃度,併與對照組20例健康人群(男8例,女12例;年齡25～40歲,平均30.5歲)結果進行比較.結果 觀察組患者THA後1 d血清中IL-6、IL-10及FBG濃度分彆為(121.74±84.93)pg/mL、(14.92±11.80)pg/mL、(4833.2±314.3)mg/L,較對照組[(41.21±25.35)pg/mL、(8.14±7.25)pg/mL、(3097.2±771.3)mg/L]及術前1 d[(47.41±76.32)pg/mL、(8.30±10.69)pg/mL、(3497.2±677.2)mg/L]明顯升高,差異均有統計學意義(P＜0.05＝.術後3 d血清中IL-6、IL-10及FBG濃度較術後1 d明顯下降(P＜0.05＝,基本接近術前水平,與術前1 d比較差異均無統計學意義(P＞0.05).結論 炎癥與血栓形成密切相關,THA後3 d是抗炎、抗凝治療的關鍵.術後及時鑑測IL-6、IL-10及FBG濃度的變化,同時觀察臨床癥狀及生化指標,對于更好地掌握病情的變化及預防血栓形成具有一定臨床意義.
목적 탐토혈청염성인자백세포개소(IL)-6、IL-10급섬유단백원(FBG)농도재인공전관관절치환술(THA)후적변화특점급의의.방법 선택초차행단측THA적30례환자위관찰조,기중남12례,녀18례;년령55～70세(평균58.4세),분별우술전1 d、술후1、3 d검측IL-6、IL-10급FBG농도,병여대조조20례건강인군(남8례,녀12례;년령25～40세,평균30.5세)결과진행비교.결과 관찰조환자THA후1 d혈청중IL-6、IL-10급FBG농도분별위(121.74±84.93)pg/mL、(14.92±11.80)pg/mL、(4833.2±314.3)mg/L,교대조조[(41.21±25.35)pg/mL、(8.14±7.25)pg/mL、(3097.2±771.3)mg/L]급술전1 d[(47.41±76.32)pg/mL、(8.30±10.69)pg/mL、(3497.2±677.2)mg/L]명현승고,차이균유통계학의의(P＜0.05＝.술후3 d혈청중IL-6、IL-10급FBG농도교술후1 d명현하강(P＜0.05＝,기본접근술전수평,여술전1 d비교차이균무통계학의의(P＞0.05).결론 염증여혈전형성밀절상관,THA후3 d시항염、항응치료적관건.술후급시감측IL-6、IL-10급FBG농도적변화,동시관찰림상증상급생화지표,대우경호지장악병정적변화급예방혈전형성구유일정림상의의.
Objective To investigate changes in the expressions of inflammatory cytokines (IL-6,IL-10) and fibrinogen (FBG) in blood serum in patients after total hip arthroplasty(THA) .Methods Thirty patients who underwent primary THA at one side were enrolled in the experimental group.They were 12 men and 18 women, aged from 55 to 70 years (mean, 58.4 years).Expressions of IL-6, IL-10 and FBG in blood serum at one day preoperation and 1, 3 days postoperation were detected respectively by ELISA.Their values were compared with the normal values of 20 healthy controls [8 men and 12 women, with a mean age of 30.5 years (from 25 to 40 years)].Results The serum IL-6, IL-10 and FBG in the experimental group one day after THA were respectively 121.74 ±84.93 pg/mL, 14.92 ± 11.80 pg/mL and 4833.2 ±314.3 mg/L, significantly higher than those one day preoperation (47.41 ±76.32 pg/mL, 8.30 ± 10.69 pg/mL and 3497.2 ± 677.2 mg/L) and those in the control group (41.21 ± 25.35 pg/mL, 8.14 ± 7.25 pg/mL and 3097.2 ±771.3 mg/L) ( P ＜ 0.05).The values 3 days postoperation significantly decreased compared to those one day postoperation ( P ＜ 0.05 ), similar to those one day preoperation.There was no significant difference between 3 days postoperation and one day preoperation ( P ＞ 0.05) .Conclusions Since inflammation is closely related to thrombosis, 1 to 3 days after THA may be the most crucial time for anti-inflammatory and anticoagulation management.To better observe treatment outcome and predict prognosis, it is essential to closely monitor IL-6, IL-10 and FBG, as well as life signs at the same time after operation.
