CAJ | 학술논문

中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在多种恶性肿瘤中都有不同程度的表达升高,并参与肿瘤的发生发展,但其对肿瘤的作用似乎存在相互矛盾的二重性.例如在乳腺癌和食管癌中通过保护MMP-9的自身降解,NGAL可促进肿瘤生长和转移.然而在胰腺癌和卵巢癌中.NGAL可通过抑制FAK的磷酸化和VEGF的合成而起到了抑制肿瘤演进的作用.本综述总结了NGAL在肿瘤发生发展中的二重性作用,并探讨引起二重性作用的可能机制.
중성립세포명효매상관지질운재단백(NGAL)재다충악성종류중도유불동정도적표체승고,병삼여종류적발생발전,단기대종류적작용사호존재상호모순적이중성.례여재유선암화식관암중통과보호MMP-9적자신강해,NGAL가촉진종류생장화전이.연이재이선암화란소암중.NGAL가통과억제FAK적린산화화VEGF적합성이기도료억제종류연진적작용.본종술총결료NGAL재종류발생발전중적이중성작용,병탐토인기이중성작용적가능궤제.
Neutrophil gelatinase associated lipocalin(NGAL),also known as lipocalin 2,has close relationship with human neoplasias,which is up-regulated in a number of malignancy and involves in the process of tumor development.But it appears to exist paradoxical effects attributed to NGAL in human neoplasias.For instance,through protecting MMP9 from autodegradation,NGAL has a clear pro-tumoral and pro-metastatic effect,as has already been observed in breast cancer and esophageal cancer.However,on the contrary,for pancreatic cancer and ovarian cancer,NGAL can inhibit FAK phosphorylation and vascular epidermal growth factor synthesis,having an anti-tumoral and anti-metastatic effect.This review summarizes the current knowledge about the dual effects of NGAL in the process of tumor development,and attempts to explore the possible underlyins mechanism.