国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2012年
1期
105-107,封3
,共4页
骨免疫学%破骨细胞%辅助性T细胞%核因子κB配体受体活化因子
骨免疫學%破骨細胞%輔助性T細胞%覈因子κB配體受體活化因子
골면역학%파골세포%보조성T세포%핵인자κB배체수체활화인자
Osteoimmunology%Osteoclast%T-helper cell%Receptor activator of nuclear factor κB ligand
骨免疫学主要研究T细胞和破骨细胞的互相作用.有研究证实,产生白细胞介素17的辅助性T细胞可诱导核因子κB配体受体活化因子在滑膜细胞上表达,并和炎症细胞因子一起刺激破骨细胞分化和骨质吸收的活性.骨免疫学对抗风湿病药物研发和风湿病治疗有重要意义.
骨免疫學主要研究T細胞和破骨細胞的互相作用.有研究證實,產生白細胞介素17的輔助性T細胞可誘導覈因子κB配體受體活化因子在滑膜細胞上錶達,併和炎癥細胞因子一起刺激破骨細胞分化和骨質吸收的活性.骨免疫學對抗風濕病藥物研髮和風濕病治療有重要意義.
골면역학주요연구T세포화파골세포적호상작용.유연구증실,산생백세포개소17적보조성T세포가유도핵인자κB배체수체활화인자재활막세포상표체,병화염증세포인자일기자격파골세포분화화골질흡수적활성.골면역학대항풍습병약물연발화풍습병치료유중요의의.
The interaction between T cell and osteoclasts is important in osteoimmunology.T-helper cells,which produce interleukin-17,induce the expression of receptor activator of nuclear factor κB ligand in synovial cells.Companied by with inflammatory cytokines,they stimulate the differentiation and activation of osteoclasts.Osteoimmunology helps us understand how antirheumatic drugs work,as well as developing new therapeutic strategies for rheumatic diseases.
